Altered dystrophin expression in the right atrium of a patient after Fontan procedure with atrial flutter.

C. J. McMahon, M. Vatta, C. D. Fraser, Jeffrey Towbin, A. C. Chang

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Underlying mechanisms in the development of atrial flutter or intra-atrial re-entry tachycardia in patients with structural cardiac abnormalities remain poorly defined. The right atrial myocardium from two patients with congenital heart disease was evaluated, of whom one presented with severe right atrial dilation and arrhythmia and the other with a normal right atrium, to assess whether increased right atrial pressure and volume overload give rise to sarcolemmal alteration. N-terminus dystrophin staining in the atrium from the patient who had undergone a Fontan procedure showed a normally distributed but significantly reduced staining signal compared with the second patient. This is the first report that patients with severe right atrial dilation and atrial flutter have marked reduction in atrial dystrophin expression.

Original languageEnglish (US)
JournalHeart (British Cardiac Society)
Volume90
Issue number12
StatePublished - Jan 1 2004
Externally publishedYes

Fingerprint

Fontan Procedure
Dystrophin
Atrial Flutter
Heart Atria
Dilatation
Staining and Labeling
Atrial Pressure
Tachycardia
Cardiac Arrhythmias
Heart Diseases
Myocardium

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine

Cite this

Altered dystrophin expression in the right atrium of a patient after Fontan procedure with atrial flutter. / McMahon, C. J.; Vatta, M.; Fraser, C. D.; Towbin, Jeffrey; Chang, A. C.

In: Heart (British Cardiac Society), Vol. 90, No. 12, 01.01.2004.

Research output: Contribution to journalArticle

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