Altered immune status in aluminum reduction plant workers

Robert Davis, Samuel Milham

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

From 1978 to 1985, B‐cell lymphoma occurred in five employees of an aluminum reduction plant (expected = 0.2; Poisson distribution). As immunodeficiency is a known risk factor for B‐cell lymphoma, we did a pilot study to evaluate immune function in apparently healthy plant workers. Twenty‐three volunteers were selected for study from 350 workers, representing a range of experience in the potroom and with exposures to strong magnetic fields and volatilized aromatic hydrocarbons. Potroom workers had significantly higher T8 levels (mean = 1,227) than non‐potroom workers (mean = 597) (p < .05, Wilcoxon rank sums) or established normal values (median = 450). T4 levels were higher for potroom workers (mean = 1,017) than for non‐potroom workers (mean = 558) or for established norms (median = 756) (p < .10, Wilcoxon rank sums). Ten of 20 potroom workers had abnormal T4/T8 ratios (<0.91) due to disproportionate elevation of the T8 subpopulation. These data suggest an underlying immune alteration in the aluminum workers studied. Further study is needed to assess the implications of abnormal T‐cell subsets in a worker population with high rates of lymphoma.

Original languageEnglish (US)
Pages (from-to)79-85
Number of pages7
JournalAmerican Journal of Industrial Medicine
Volume18
Issue number1
DOIs
StatePublished - Jan 1 1990
Externally publishedYes

Fingerprint

Aluminum
Lymphoma
Poisson Distribution
Aromatic Hydrocarbons
CD4-CD8 Ratio
Magnetic Fields
Volunteers
Reference Values
Population

All Science Journal Classification (ASJC) codes

  • Public Health, Environmental and Occupational Health

Cite this

Altered immune status in aluminum reduction plant workers. / Davis, Robert; Milham, Samuel.

In: American Journal of Industrial Medicine, Vol. 18, No. 1, 01.01.1990, p. 79-85.

Research output: Contribution to journalArticle

@article{6b043ef969dc4d70a3dbfbf70b730574,
title = "Altered immune status in aluminum reduction plant workers",
abstract = "From 1978 to 1985, B‐cell lymphoma occurred in five employees of an aluminum reduction plant (expected = 0.2; Poisson distribution). As immunodeficiency is a known risk factor for B‐cell lymphoma, we did a pilot study to evaluate immune function in apparently healthy plant workers. Twenty‐three volunteers were selected for study from 350 workers, representing a range of experience in the potroom and with exposures to strong magnetic fields and volatilized aromatic hydrocarbons. Potroom workers had significantly higher T8 levels (mean = 1,227) than non‐potroom workers (mean = 597) (p < .05, Wilcoxon rank sums) or established normal values (median = 450). T4 levels were higher for potroom workers (mean = 1,017) than for non‐potroom workers (mean = 558) or for established norms (median = 756) (p < .10, Wilcoxon rank sums). Ten of 20 potroom workers had abnormal T4/T8 ratios (<0.91) due to disproportionate elevation of the T8 subpopulation. These data suggest an underlying immune alteration in the aluminum workers studied. Further study is needed to assess the implications of abnormal T‐cell subsets in a worker population with high rates of lymphoma.",
author = "Robert Davis and Samuel Milham",
year = "1990",
month = "1",
day = "1",
doi = "10.1002/ajim.4700180109",
language = "English (US)",
volume = "18",
pages = "79--85",
journal = "American Journal of Industrial Medicine",
issn = "0271-3586",
publisher = "Wiley-Liss Inc.",
number = "1",

}

TY - JOUR

T1 - Altered immune status in aluminum reduction plant workers

AU - Davis, Robert

AU - Milham, Samuel

PY - 1990/1/1

Y1 - 1990/1/1

N2 - From 1978 to 1985, B‐cell lymphoma occurred in five employees of an aluminum reduction plant (expected = 0.2; Poisson distribution). As immunodeficiency is a known risk factor for B‐cell lymphoma, we did a pilot study to evaluate immune function in apparently healthy plant workers. Twenty‐three volunteers were selected for study from 350 workers, representing a range of experience in the potroom and with exposures to strong magnetic fields and volatilized aromatic hydrocarbons. Potroom workers had significantly higher T8 levels (mean = 1,227) than non‐potroom workers (mean = 597) (p < .05, Wilcoxon rank sums) or established normal values (median = 450). T4 levels were higher for potroom workers (mean = 1,017) than for non‐potroom workers (mean = 558) or for established norms (median = 756) (p < .10, Wilcoxon rank sums). Ten of 20 potroom workers had abnormal T4/T8 ratios (<0.91) due to disproportionate elevation of the T8 subpopulation. These data suggest an underlying immune alteration in the aluminum workers studied. Further study is needed to assess the implications of abnormal T‐cell subsets in a worker population with high rates of lymphoma.

AB - From 1978 to 1985, B‐cell lymphoma occurred in five employees of an aluminum reduction plant (expected = 0.2; Poisson distribution). As immunodeficiency is a known risk factor for B‐cell lymphoma, we did a pilot study to evaluate immune function in apparently healthy plant workers. Twenty‐three volunteers were selected for study from 350 workers, representing a range of experience in the potroom and with exposures to strong magnetic fields and volatilized aromatic hydrocarbons. Potroom workers had significantly higher T8 levels (mean = 1,227) than non‐potroom workers (mean = 597) (p < .05, Wilcoxon rank sums) or established normal values (median = 450). T4 levels were higher for potroom workers (mean = 1,017) than for non‐potroom workers (mean = 558) or for established norms (median = 756) (p < .10, Wilcoxon rank sums). Ten of 20 potroom workers had abnormal T4/T8 ratios (<0.91) due to disproportionate elevation of the T8 subpopulation. These data suggest an underlying immune alteration in the aluminum workers studied. Further study is needed to assess the implications of abnormal T‐cell subsets in a worker population with high rates of lymphoma.

UR - http://www.scopus.com/inward/record.url?scp=0024989884&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0024989884&partnerID=8YFLogxK

U2 - 10.1002/ajim.4700180109

DO - 10.1002/ajim.4700180109

M3 - Article

VL - 18

SP - 79

EP - 85

JO - American Journal of Industrial Medicine

JF - American Journal of Industrial Medicine

SN - 0271-3586

IS - 1

ER -