Altered sensitivity of osmotically stimulated vasopressin release in quadriplegic subjects

B. M. Wall, H. H. Williams, D. N. Presley, J. T. Crofton, E. G. Schneider, L. Share, C. R. Cooke

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Osmoregulation of vasopressin release was studied in 15 quadriplegic subjects (Quad) and 7 healthy control subjects (Con). Hypertonic NaCl (0.85 M) was infused intravenously (0.05 ml·kg-1·min-1) over 90 min in studies on supine subjects and in comparable studies on the same subjects erect (sitting). Erect posture in Quad, but not in Con, was accompanied by orthostatic reductions in arterial blood pressure and by significantly increased plasma aldosterone (P < 0.001) and cortisol (P < 0.001) concentrations and increased plasma renin activity (P < 0.025). Changes in plasma arginine vasopressin concentration (P(AVP)) during hypertonic NaCl infusions were also greater in erect than in supine Quad (P < 0.005), despite identical changes in plasma osmolality (P(osm)). Linear regression analysis of the P(AVP)/P(osm) relationship during hypertonic NaCl infusions showed highly significant correlations (P < 0.0002) in both Quad and Con. Mean slope values for regression lines, however, were significantly higher in erect than in supine Quad (P < 0.005) but did not differ in relation to posture in Con. Differences in posture were not associated with differences in abscissal intercepts in either Quad or Con. These studies show significant alterations in the sensitivity of osmotically stimulated vasopressin release related to differences in posture in Quad, characterized by enhanced sensitivity in erect posture due to nonosmotic stimuli not evident in Con.

Original languageEnglish (US)
Pages (from-to)R827-R835
JournalAmerican Journal of Physiology - Regulatory Integrative and Comparative Physiology
Volume258
Issue number4 27-4
StatePublished - Jan 1 1990

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Vasopressins
Posture
Arginine Vasopressin
Osmoregulation
Aldosterone
Renin
Osmolar Concentration
Hydrocortisone
Linear Models
Healthy Volunteers
Arterial Pressure
Regression Analysis

All Science Journal Classification (ASJC) codes

  • Physiology
  • Physiology (medical)

Cite this

Wall, B. M., Williams, H. H., Presley, D. N., Crofton, J. T., Schneider, E. G., Share, L., & Cooke, C. R. (1990). Altered sensitivity of osmotically stimulated vasopressin release in quadriplegic subjects. American Journal of Physiology - Regulatory Integrative and Comparative Physiology, 258(4 27-4), R827-R835.

Altered sensitivity of osmotically stimulated vasopressin release in quadriplegic subjects. / Wall, B. M.; Williams, H. H.; Presley, D. N.; Crofton, J. T.; Schneider, E. G.; Share, L.; Cooke, C. R.

In: American Journal of Physiology - Regulatory Integrative and Comparative Physiology, Vol. 258, No. 4 27-4, 01.01.1990, p. R827-R835.

Research output: Contribution to journalArticle

Wall, BM, Williams, HH, Presley, DN, Crofton, JT, Schneider, EG, Share, L & Cooke, CR 1990, 'Altered sensitivity of osmotically stimulated vasopressin release in quadriplegic subjects', American Journal of Physiology - Regulatory Integrative and Comparative Physiology, vol. 258, no. 4 27-4, pp. R827-R835.
Wall, B. M. ; Williams, H. H. ; Presley, D. N. ; Crofton, J. T. ; Schneider, E. G. ; Share, L. ; Cooke, C. R. / Altered sensitivity of osmotically stimulated vasopressin release in quadriplegic subjects. In: American Journal of Physiology - Regulatory Integrative and Comparative Physiology. 1990 ; Vol. 258, No. 4 27-4. pp. R827-R835.
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