Aluminum Accumulation in Patients with Chronic Renal Disease

Leigh Quarles, Marc K. Drezner, Isidro B. Salusky, Joanne Foley, Pauline Nelson, William G. Goodman

Research output: Contribution to journalLetter

2 Citations (Scopus)

Abstract

To the Editor: Although epidemiologic studies show that the accumulation of aluminum in patients with end-stage renal disease, due to the use of contaminated dialysate fluid, causes low-turnover osteomalacia,1 the potential toxicity of lower levels of aluminum exposure due to the ingestion of aluminum-containing antacids has not been established. The study of Salusky et al. (Feb. 21 issue)2 provides the first prospective, controlled trial to evaluate the potential toxicity of oral aluminum hydroxide in patients with end-stage renal disease. However, we believe that the results are insufficient to support the conclusion that the risk of aluminum toxicity precludes the use.

Original languageEnglish (US)
Pages (from-to)208-209
Number of pages2
JournalNew England Journal of Medicine
Volume325
Issue number3
DOIs
StatePublished - Jul 18 1991
Externally publishedYes

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Aluminum
Chronic Renal Insufficiency
Chronic Kidney Failure
Aluminum Hydroxide
Osteomalacia
Antacids
Dialysis Solutions
Epidemiologic Studies
Eating

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

Quarles, L., Drezner, M. K., Salusky, I. B., Foley, J., Nelson, P., & Goodman, W. G. (1991). Aluminum Accumulation in Patients with Chronic Renal Disease. New England Journal of Medicine, 325(3), 208-209. https://doi.org/10.1056/NEJM199107183250314

Aluminum Accumulation in Patients with Chronic Renal Disease. / Quarles, Leigh; Drezner, Marc K.; Salusky, Isidro B.; Foley, Joanne; Nelson, Pauline; Goodman, William G.

In: New England Journal of Medicine, Vol. 325, No. 3, 18.07.1991, p. 208-209.

Research output: Contribution to journalLetter

Quarles, L, Drezner, MK, Salusky, IB, Foley, J, Nelson, P & Goodman, WG 1991, 'Aluminum Accumulation in Patients with Chronic Renal Disease', New England Journal of Medicine, vol. 325, no. 3, pp. 208-209. https://doi.org/10.1056/NEJM199107183250314
Quarles, Leigh ; Drezner, Marc K. ; Salusky, Isidro B. ; Foley, Joanne ; Nelson, Pauline ; Goodman, William G. / Aluminum Accumulation in Patients with Chronic Renal Disease. In: New England Journal of Medicine. 1991 ; Vol. 325, No. 3. pp. 208-209.
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