Alveolar soft-part sarcoma of the urinary bladder with urethral recurrence

A unique case with emphasis on differential diagnoses and diagnostic utility of an immunohistochemical panel including TFE3

Mahul Amin, Rajiv M. Patel, Pedro Oliveira, Rafael Cabrera, Victor Carneiro, Mota Preto, Bonnie Balzer, Andrew L. Folpe

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

Alveolar soft-part sarcoma (ASPS) is a rare, clinically, morphologically, ultrastructurally, and cytogenetically distinctive malignant mesenchymal tumor that most classically occurs in the extremities of adolescents and young adults, but has also been described in a number of unusual sites. The molecular signature of ASPS is a specific der(17)t(X;17)(p11.2;q25) translocation, which results in the fusion of TFE3 transcription factor gene (from Xp11) with ASPL at 17q25. The ASPL-TFE3 fusion protein encoded by the fusion transcript can be detected immunohistochemically with commercially available antibodies to the carboxy terminus of TFE3. Herein, we report a unique case of ASPS presenting in the bladder with subsequent urethral recurrence in a 25-year-old woman. We emphasize the differential diagnoses engendered by ASPS including common, not-so-common, and rare tumors involving the urinary bladder that have a nested architecture, and both clear and eosinophilic cytoplasm, and demonstrate the utility of a broad immunohistochemistry panel including TFE3 for diagnosis.

Original languageEnglish (US)
Pages (from-to)1322-1325
Number of pages4
JournalAmerican Journal of Surgical Pathology
Volume30
Issue number10
DOIs
StatePublished - Oct 1 2006

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Alveolar Soft Part Sarcoma
Urinary Bladder
Differential Diagnosis
Recurrence
Young Adult
Cytoplasm
Transcription Factors
Extremities
Immunohistochemistry
Antibodies
Genes
Neoplasms
Proteins

All Science Journal Classification (ASJC) codes

  • Anatomy
  • Surgery
  • Pathology and Forensic Medicine

Cite this

Alveolar soft-part sarcoma of the urinary bladder with urethral recurrence : A unique case with emphasis on differential diagnoses and diagnostic utility of an immunohistochemical panel including TFE3. / Amin, Mahul; Patel, Rajiv M.; Oliveira, Pedro; Cabrera, Rafael; Carneiro, Victor; Preto, Mota; Balzer, Bonnie; Folpe, Andrew L.

In: American Journal of Surgical Pathology, Vol. 30, No. 10, 01.10.2006, p. 1322-1325.

Research output: Contribution to journalArticle

Amin, Mahul ; Patel, Rajiv M. ; Oliveira, Pedro ; Cabrera, Rafael ; Carneiro, Victor ; Preto, Mota ; Balzer, Bonnie ; Folpe, Andrew L. / Alveolar soft-part sarcoma of the urinary bladder with urethral recurrence : A unique case with emphasis on differential diagnoses and diagnostic utility of an immunohistochemical panel including TFE3. In: American Journal of Surgical Pathology. 2006 ; Vol. 30, No. 10. pp. 1322-1325.
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