AMPA receptor-mediated EPSCs in rat neocortical layer II/III interneurons have rapid kinetics

Fuming Zhou, John J. Hablitz

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

The properties of spontaneous and miniature (m) AMPA receptor-mediated excitatory postsynaptic currents (EPSCs) were studied in rat neocortical layer II/III fast spiking interneurons. Under optimal recording conditions, averaged mEPSCs had a 10-90% rise time of about 0.3 ms. The decay of averaged mEPSCs was double exponential with time constants of about 1 and 4 ms. Kinetics were observed to slow as series resistance increased. The amplitudes of mEPSCs were much smaller at + 50 mV than at - 50 mV indicating that the currents were inwardly rectifying. These results suggest that synaptic AMPA receptors on neocortical inhibitory interneurons have a deactivation time constant less than 1 ms which largely determines the decay of the synaptic currents. The receptors appear to lack GluR-2 subunits and may be Ca2+ permeable.

Original languageEnglish (US)
Pages (from-to)166-169
Number of pages4
JournalBrain Research
Volume780
Issue number1
DOIs
StatePublished - Jan 5 1998

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AMPA Receptors
Excitatory Postsynaptic Potentials
Interneurons
Neurotransmitter Receptor

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

Cite this

AMPA receptor-mediated EPSCs in rat neocortical layer II/III interneurons have rapid kinetics. / Zhou, Fuming; Hablitz, John J.

In: Brain Research, Vol. 780, No. 1, 05.01.1998, p. 166-169.

Research output: Contribution to journalArticle

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