An anterograde HRP study of retinal projections to the hypothalamus in the rat

Hitoshi Kita, Yutaka Oomura

Research output: Contribution to journalArticle

40 Citations (Scopus)

Abstract

Retinal projections to the hypothalamus in the rat were examined using anterograde transport of horseradish peroxidase (HRP). After intraocular HRP injections, retinohypothalamic fibers were histochemically visualized by a highly sensitive HRP procedure using benzidine. Light microscopic evaluation of HRP labeling in the hypothalamus confirmed a retinal projection to the suprachiasmatic nucleus (SCN). In the rostral part of the SCN labeling was observed in the ventromedial, ventral and the ventrolateral regions and was heavier on the contralateral than the ipsilateral site to the injected eye. In the most caudal part of the SCN labeling was observed in the medial region and was almost equal in amount bilaterally. Further, this study clearly demonstrates a new retinal fiber trajectory to the lateral hypothalamic area (LHA). Some labeled retinal fibers were segregated from the dorsolateral margin of the main optic tract and continued into the LHA, supporting the notion of direct retino-LHA projections.

Original languageEnglish (US)
Pages (from-to)249-253
Number of pages5
JournalBrain Research Bulletin
Volume8
Issue number3
DOIs
StatePublished - Jan 1 1982
Externally publishedYes

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Horseradish Peroxidase
Lateral Hypothalamic Area
Suprachiasmatic Nucleus
Hypothalamus
Light
Injections

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)

Cite this

An anterograde HRP study of retinal projections to the hypothalamus in the rat. / Kita, Hitoshi; Oomura, Yutaka.

In: Brain Research Bulletin, Vol. 8, No. 3, 01.01.1982, p. 249-253.

Research output: Contribution to journalArticle

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