An efficient route to 3-substituted cyclobutanone derivatives

George Kabalka, Min Liang Yao

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

An efficient route to 3-(hydroxymethyl)cyclobutanone acetals via a [2+2] cycloaddition reaction is reported. The dramatic effect of different diol acetals on benzyl deprotection is discussed. Efficient synthesis of two synthetically useful intermediates, 3-methylenecyclobutanone acetal and 3-(bromomethyl)cyclobutanone, are provided.

Original languageEnglish (US)
Pages (from-to)1879-1881
Number of pages3
JournalTetrahedron Letters
Volume44
Issue number9
DOIs
StatePublished - Feb 24 2003
Externally publishedYes

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Acetals
Derivatives
Cycloaddition
Cycloaddition Reaction

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

Cite this

An efficient route to 3-substituted cyclobutanone derivatives. / Kabalka, George; Yao, Min Liang.

In: Tetrahedron Letters, Vol. 44, No. 9, 24.02.2003, p. 1879-1881.

Research output: Contribution to journalArticle

Kabalka, George ; Yao, Min Liang. / An efficient route to 3-substituted cyclobutanone derivatives. In: Tetrahedron Letters. 2003 ; Vol. 44, No. 9. pp. 1879-1881.
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