An exploratory study of respiratory quotient calibration and association with postmenopausal breast cancer

Ross L. Prentice, Marian L. Neuhouser, Lesley F. Tinker, Mary Pettinger, Cynthia A. Thomson, Yasmin Mossavar-Rahmani, Fridtjof Thomas, Lihong Qi, Ying Huang

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Background: The respiratory quotient (RQ), defined as the ratio of carbon dioxide exhaled to oxygen uptake, reflects substrate utilization when energy is expended. Fat and alcohol have RQ values of approximately 0.7, compared with 1.0 for carbohydrate, and approximately 0.8 for protein. Here, the association between RQ and postmenopausal breast cancer risk is studied. Methods: Paired RQ measurements were obtained, separated by approximately 6 months, for women in the reliability subset of a Women's Health Initiative (WHI) Nutrition and Physical Activity Assessment Study. Linear regression of the average of the paired log RQ assessments on a corresponding log food quotient (FQ) average and other study subject characteristics, including age, body mass index, race, and education, yielded calibration equations for predicting RQ. Results: Calibration equations, using any of food frequency, food record, or dietary recall data, explained an appreciable fraction of measured log RQ variation, and these were used to compute calibrated RQ estimates throughout WHI cohorts. Calibrated RQ estimates using 4-day food record (4DFR) data related inversely (P = 0.004) to (invasive) breast cancer risk in the WHI Dietary Modification trial comparison group, and corresponding RQ estimates using food-frequency data related inversely (P = 0.002) to breast cancer incidence in this cohort combined with the larger WHI observational study. Conclusion: Although preliminary, these analyses suggest a substantially higher postmenopausal breast cancer risk among women having relatively low RQ. Impact: RQ elevation could provide a novel target for breast cancer risk reduction.

Original languageEnglish (US)
Pages (from-to)2374-2383
Number of pages10
JournalCancer Epidemiology Biomarkers and Prevention
Volume22
Issue number12
DOIs
StatePublished - Dec 1 2013

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Calibration
Women's Health
Breast Neoplasms
Food
Diet Therapy
Diet Records
Risk Reduction Behavior
Carbon Dioxide
Observational Studies
Linear Models
Body Mass Index
Fats
Alcohols
Carbohydrates
Exercise
Oxygen
Education
Incidence
Proteins

All Science Journal Classification (ASJC) codes

  • Epidemiology
  • Oncology

Cite this

Prentice, R. L., Neuhouser, M. L., Tinker, L. F., Pettinger, M., Thomson, C. A., Mossavar-Rahmani, Y., ... Huang, Y. (2013). An exploratory study of respiratory quotient calibration and association with postmenopausal breast cancer. Cancer Epidemiology Biomarkers and Prevention, 22(12), 2374-2383. https://doi.org/10.1158/1055-9965.EPI-13-0511

An exploratory study of respiratory quotient calibration and association with postmenopausal breast cancer. / Prentice, Ross L.; Neuhouser, Marian L.; Tinker, Lesley F.; Pettinger, Mary; Thomson, Cynthia A.; Mossavar-Rahmani, Yasmin; Thomas, Fridtjof; Qi, Lihong; Huang, Ying.

In: Cancer Epidemiology Biomarkers and Prevention, Vol. 22, No. 12, 01.12.2013, p. 2374-2383.

Research output: Contribution to journalArticle

Prentice, RL, Neuhouser, ML, Tinker, LF, Pettinger, M, Thomson, CA, Mossavar-Rahmani, Y, Thomas, F, Qi, L & Huang, Y 2013, 'An exploratory study of respiratory quotient calibration and association with postmenopausal breast cancer', Cancer Epidemiology Biomarkers and Prevention, vol. 22, no. 12, pp. 2374-2383. https://doi.org/10.1158/1055-9965.EPI-13-0511
Prentice, Ross L. ; Neuhouser, Marian L. ; Tinker, Lesley F. ; Pettinger, Mary ; Thomson, Cynthia A. ; Mossavar-Rahmani, Yasmin ; Thomas, Fridtjof ; Qi, Lihong ; Huang, Ying. / An exploratory study of respiratory quotient calibration and association with postmenopausal breast cancer. In: Cancer Epidemiology Biomarkers and Prevention. 2013 ; Vol. 22, No. 12. pp. 2374-2383.
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