An intracellular protein that binds amyloid-β peptide and mediates neurotoxicity in Alzheimer's disease

Shi Du Yan, Jin Fu, Claudio Soto, Xi Chen, Huaijie Zhu, Futwan Al-Mohanna, Kate Collison, Aiping Zhu, Eric Stern, Takaomi Saido, Masaya Tohyama, Satoshi Ogawa, Alex Roher, David Stern

Research output: Contribution to journalArticle

310 Citations (Scopus)

Abstract

Amyloid-β is a neurotoxic peptide which is implicated in the pathogenesis of Alzheimer's disease. It binds an intracellular polypeptide known as ERAB, thought to be a hydroxysteroid dehydrogenase enzyme, which is expressed In normal tissues, but is overexpressed in neurons affected in Alzheimer's disease. ERAB Immunoprecipitates with amyloid-β, and when call cultures are exposed to amyloid-β, ERAB inside the cell is rapidly redistributed to the plasma membrane. The toxic effect of amyloid-β on these cells is prevented by blocking ERAB and is enhanced by overexpression of ERAB. By interacting with intracellular amyloid-β, ERAB may therefore contribute to the neuronal dysfunction associated with Alzhelmer's disease.

Original languageEnglish (US)
Pages (from-to)689-695
Number of pages7
JournalNature
Volume389
Issue number6652
DOIs
StatePublished - Nov 5 1997
Externally publishedYes

Fingerprint

Amyloidogenic Proteins
Amyloid
Alzheimer Disease
Peptides
Hydroxysteroid Dehydrogenases
Poisons
Cell Membrane
Neurons
Enzymes

All Science Journal Classification (ASJC) codes

  • General

Cite this

An intracellular protein that binds amyloid-β peptide and mediates neurotoxicity in Alzheimer's disease. / Yan, Shi Du; Fu, Jin; Soto, Claudio; Chen, Xi; Zhu, Huaijie; Al-Mohanna, Futwan; Collison, Kate; Zhu, Aiping; Stern, Eric; Saido, Takaomi; Tohyama, Masaya; Ogawa, Satoshi; Roher, Alex; Stern, David.

In: Nature, Vol. 389, No. 6652, 05.11.1997, p. 689-695.

Research output: Contribution to journalArticle

Yan, SD, Fu, J, Soto, C, Chen, X, Zhu, H, Al-Mohanna, F, Collison, K, Zhu, A, Stern, E, Saido, T, Tohyama, M, Ogawa, S, Roher, A & Stern, D 1997, 'An intracellular protein that binds amyloid-β peptide and mediates neurotoxicity in Alzheimer's disease', Nature, vol. 389, no. 6652, pp. 689-695. https://doi.org/10.1038/39522
Yan, Shi Du ; Fu, Jin ; Soto, Claudio ; Chen, Xi ; Zhu, Huaijie ; Al-Mohanna, Futwan ; Collison, Kate ; Zhu, Aiping ; Stern, Eric ; Saido, Takaomi ; Tohyama, Masaya ; Ogawa, Satoshi ; Roher, Alex ; Stern, David. / An intracellular protein that binds amyloid-β peptide and mediates neurotoxicity in Alzheimer's disease. In: Nature. 1997 ; Vol. 389, No. 6652. pp. 689-695.
@article{2bba64e71b22445cbe97ca7a1c305f8d,
title = "An intracellular protein that binds amyloid-β peptide and mediates neurotoxicity in Alzheimer's disease",
abstract = "Amyloid-β is a neurotoxic peptide which is implicated in the pathogenesis of Alzheimer's disease. It binds an intracellular polypeptide known as ERAB, thought to be a hydroxysteroid dehydrogenase enzyme, which is expressed In normal tissues, but is overexpressed in neurons affected in Alzheimer's disease. ERAB Immunoprecipitates with amyloid-β, and when call cultures are exposed to amyloid-β, ERAB inside the cell is rapidly redistributed to the plasma membrane. The toxic effect of amyloid-β on these cells is prevented by blocking ERAB and is enhanced by overexpression of ERAB. By interacting with intracellular amyloid-β, ERAB may therefore contribute to the neuronal dysfunction associated with Alzhelmer's disease.",
author = "Yan, {Shi Du} and Jin Fu and Claudio Soto and Xi Chen and Huaijie Zhu and Futwan Al-Mohanna and Kate Collison and Aiping Zhu and Eric Stern and Takaomi Saido and Masaya Tohyama and Satoshi Ogawa and Alex Roher and David Stern",
year = "1997",
month = "11",
day = "5",
doi = "10.1038/39522",
language = "English (US)",
volume = "389",
pages = "689--695",
journal = "Nature",
issn = "0028-0836",
publisher = "Nature Publishing Group",
number = "6652",

}

TY - JOUR

T1 - An intracellular protein that binds amyloid-β peptide and mediates neurotoxicity in Alzheimer's disease

AU - Yan, Shi Du

AU - Fu, Jin

AU - Soto, Claudio

AU - Chen, Xi

AU - Zhu, Huaijie

AU - Al-Mohanna, Futwan

AU - Collison, Kate

AU - Zhu, Aiping

AU - Stern, Eric

AU - Saido, Takaomi

AU - Tohyama, Masaya

AU - Ogawa, Satoshi

AU - Roher, Alex

AU - Stern, David

PY - 1997/11/5

Y1 - 1997/11/5

N2 - Amyloid-β is a neurotoxic peptide which is implicated in the pathogenesis of Alzheimer's disease. It binds an intracellular polypeptide known as ERAB, thought to be a hydroxysteroid dehydrogenase enzyme, which is expressed In normal tissues, but is overexpressed in neurons affected in Alzheimer's disease. ERAB Immunoprecipitates with amyloid-β, and when call cultures are exposed to amyloid-β, ERAB inside the cell is rapidly redistributed to the plasma membrane. The toxic effect of amyloid-β on these cells is prevented by blocking ERAB and is enhanced by overexpression of ERAB. By interacting with intracellular amyloid-β, ERAB may therefore contribute to the neuronal dysfunction associated with Alzhelmer's disease.

AB - Amyloid-β is a neurotoxic peptide which is implicated in the pathogenesis of Alzheimer's disease. It binds an intracellular polypeptide known as ERAB, thought to be a hydroxysteroid dehydrogenase enzyme, which is expressed In normal tissues, but is overexpressed in neurons affected in Alzheimer's disease. ERAB Immunoprecipitates with amyloid-β, and when call cultures are exposed to amyloid-β, ERAB inside the cell is rapidly redistributed to the plasma membrane. The toxic effect of amyloid-β on these cells is prevented by blocking ERAB and is enhanced by overexpression of ERAB. By interacting with intracellular amyloid-β, ERAB may therefore contribute to the neuronal dysfunction associated with Alzhelmer's disease.

UR - http://www.scopus.com/inward/record.url?scp=0013079948&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0013079948&partnerID=8YFLogxK

U2 - 10.1038/39522

DO - 10.1038/39522

M3 - Article

VL - 389

SP - 689

EP - 695

JO - Nature

JF - Nature

SN - 0028-0836

IS - 6652

ER -