An unusual cause of flaccid paralysis and coma

Baclofen overdose

Elena Caron, Robin Morgan, James Wheless

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Baclofen is a γ-aminobutyric acid (GABA) agonist that is commonly prescribed for the treatment of spasticity in children. The clinical indications for baclofen use in the pediatric population have increased in recent years. Prescribing baclofen mandates education regarding abrupt withdrawal and overdose because of the severe clinical reactions this can precipitate. This report highlights the case of a patient who presented with acute onset of coma and a flaccid paralysis after baclofen overdose. We reviewed the presentation, clinical course, diagnostic studies, and outcome of this patient. A review of prior literature regarding baclofen overdose is included. Baclofen overdose is heralded by dose-related alteration in consciousness and weakness, progressing to coma and a flaccid paralysis. Screening for baclofen overdose is accomplished through high-power liquid chromatography. Baclofen overdose is treated with supportive care and antiepileptic medications as indicated. There is usually full spontaneous recovery with elimination of the medication.

Original languageEnglish (US)
Pages (from-to)555-559
Number of pages5
JournalJournal of Child Neurology
Volume29
Issue number4
DOIs
StatePublished - Jan 1 2014

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Baclofen
Coma
Paralysis
GABA Agonists
Aminobutyrates
Consciousness
Liquid Chromatography
Anticonvulsants
Outcome Assessment (Health Care)
Pediatrics
Education

All Science Journal Classification (ASJC) codes

  • Clinical Neurology
  • Pediatrics, Perinatology, and Child Health
  • Medicine(all)

Cite this

An unusual cause of flaccid paralysis and coma : Baclofen overdose. / Caron, Elena; Morgan, Robin; Wheless, James.

In: Journal of Child Neurology, Vol. 29, No. 4, 01.01.2014, p. 555-559.

Research output: Contribution to journalArticle

Caron, Elena ; Morgan, Robin ; Wheless, James. / An unusual cause of flaccid paralysis and coma : Baclofen overdose. In: Journal of Child Neurology. 2014 ; Vol. 29, No. 4. pp. 555-559.
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