Anabolic steroids and craniofacial growth in the rat.

R. L. Barrett, Edward Harris

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Anabolic steroids are misused by adolescents as well as adults to increase muscle and improve appearance and athletic performance. Since these substances strongly enhance protein synthesis, it was speculated that craniofacial changes in bone size and, perhaps, skeletodental relationships might also occur. Eighty rat pups were divided into three groups: (1) sham-treated controls, (2) a low-dose group (1 mg/kg/wk nandrolone phenpropionate), and (3) a high-dose group (10 mg/kg/wk). The high-dose regimen more closely mimics dosages used by abusers. Steroid therapy significantly increased all measures of the craniofacial complex (k = 20)--on the order of 3.5%-except some precocious calvarial dimensions. Importantly, significant alterations also occurred in facial morphology. The low-dose group exhibited proportionate increases in most craniofacial dimensions, but the high-dose produced overt shape changes, notably a maxillomandibular, anteroposterior jaw discrepancy due to maxillary excess. In sum, this anabolic steroid significantly altered facial growth in this animal model; by extension, steroid abuse by adolescent humans may produce discernible changes in their craniofacial complexes.

Original languageEnglish (US)
Pages (from-to)289-298
Number of pages10
JournalAngle Orthodontist
Volume63
Issue number4
StatePublished - Dec 1 1993

Fingerprint

Testosterone Congeners
Steroids
Athletic Performance
Growth
Jaw
Animal Models
Bone and Bones
Muscles
Proteins
Therapeutics

All Science Journal Classification (ASJC) codes

  • Orthodontics

Cite this

Anabolic steroids and craniofacial growth in the rat. / Barrett, R. L.; Harris, Edward.

In: Angle Orthodontist, Vol. 63, No. 4, 01.12.1993, p. 289-298.

Research output: Contribution to journalArticle

Barrett, R. L. ; Harris, Edward. / Anabolic steroids and craniofacial growth in the rat. In: Angle Orthodontist. 1993 ; Vol. 63, No. 4. pp. 289-298.
@article{09138487d4294d8292e01127749c8217,
title = "Anabolic steroids and craniofacial growth in the rat.",
abstract = "Anabolic steroids are misused by adolescents as well as adults to increase muscle and improve appearance and athletic performance. Since these substances strongly enhance protein synthesis, it was speculated that craniofacial changes in bone size and, perhaps, skeletodental relationships might also occur. Eighty rat pups were divided into three groups: (1) sham-treated controls, (2) a low-dose group (1 mg/kg/wk nandrolone phenpropionate), and (3) a high-dose group (10 mg/kg/wk). The high-dose regimen more closely mimics dosages used by abusers. Steroid therapy significantly increased all measures of the craniofacial complex (k = 20)--on the order of 3.5{\%}-except some precocious calvarial dimensions. Importantly, significant alterations also occurred in facial morphology. The low-dose group exhibited proportionate increases in most craniofacial dimensions, but the high-dose produced overt shape changes, notably a maxillomandibular, anteroposterior jaw discrepancy due to maxillary excess. In sum, this anabolic steroid significantly altered facial growth in this animal model; by extension, steroid abuse by adolescent humans may produce discernible changes in their craniofacial complexes.",
author = "Barrett, {R. L.} and Edward Harris",
year = "1993",
month = "12",
day = "1",
language = "English (US)",
volume = "63",
pages = "289--298",
journal = "Angle Orthodontist",
issn = "0003-3219",
publisher = "E H Angle Orthodontists Research & Education Foundation, Inc.",
number = "4",

}

TY - JOUR

T1 - Anabolic steroids and craniofacial growth in the rat.

AU - Barrett, R. L.

AU - Harris, Edward

PY - 1993/12/1

Y1 - 1993/12/1

N2 - Anabolic steroids are misused by adolescents as well as adults to increase muscle and improve appearance and athletic performance. Since these substances strongly enhance protein synthesis, it was speculated that craniofacial changes in bone size and, perhaps, skeletodental relationships might also occur. Eighty rat pups were divided into three groups: (1) sham-treated controls, (2) a low-dose group (1 mg/kg/wk nandrolone phenpropionate), and (3) a high-dose group (10 mg/kg/wk). The high-dose regimen more closely mimics dosages used by abusers. Steroid therapy significantly increased all measures of the craniofacial complex (k = 20)--on the order of 3.5%-except some precocious calvarial dimensions. Importantly, significant alterations also occurred in facial morphology. The low-dose group exhibited proportionate increases in most craniofacial dimensions, but the high-dose produced overt shape changes, notably a maxillomandibular, anteroposterior jaw discrepancy due to maxillary excess. In sum, this anabolic steroid significantly altered facial growth in this animal model; by extension, steroid abuse by adolescent humans may produce discernible changes in their craniofacial complexes.

AB - Anabolic steroids are misused by adolescents as well as adults to increase muscle and improve appearance and athletic performance. Since these substances strongly enhance protein synthesis, it was speculated that craniofacial changes in bone size and, perhaps, skeletodental relationships might also occur. Eighty rat pups were divided into three groups: (1) sham-treated controls, (2) a low-dose group (1 mg/kg/wk nandrolone phenpropionate), and (3) a high-dose group (10 mg/kg/wk). The high-dose regimen more closely mimics dosages used by abusers. Steroid therapy significantly increased all measures of the craniofacial complex (k = 20)--on the order of 3.5%-except some precocious calvarial dimensions. Importantly, significant alterations also occurred in facial morphology. The low-dose group exhibited proportionate increases in most craniofacial dimensions, but the high-dose produced overt shape changes, notably a maxillomandibular, anteroposterior jaw discrepancy due to maxillary excess. In sum, this anabolic steroid significantly altered facial growth in this animal model; by extension, steroid abuse by adolescent humans may produce discernible changes in their craniofacial complexes.

UR - http://www.scopus.com/inward/record.url?scp=0027741718&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0027741718&partnerID=8YFLogxK

M3 - Article

VL - 63

SP - 289

EP - 298

JO - Angle Orthodontist

JF - Angle Orthodontist

SN - 0003-3219

IS - 4

ER -