Analysis of candidate genes of spontaneous arthritis inmice deficient for interleukin-1 receptor antagonist

Yanhong Cao, Caijuan Li, Jian Yan, Feng Jiao, Xiao Yun Liu, Karen Hasty, John Stuart, Weikuan Gu, Yan Jiao

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Previously, we identified a major quantitative trait locus (QTL) on mouse chromosome 1 that regulates the susceptibility to arthritis in an F2 population generated from arthritis-prone BALB/c and arthritis-resistant DBA/1 mice deficient for interleukin-1 receptor antagonist. To further select candidate genes for the QTL, we analyzed the expression patterns of arthritis in 38 F2 individuals and compared the expression levels of key candidate genes to the parental strains. Two distinct subpopulations of arthritic mice were identified in the 38 F2 mice. One subgroup of diseased mice was characterized by myeloid cell dominant inflammation, whereas the other was mainly associated with increased anti-apoptotic activities of inflammatory cells. Several differentially expressed important candidate genes in parental strains in the QTL region are relevant to myeloid cell, apoptotic activities, or to both. About one-quarter of those genes have been previously linked to arthritis in literature. The present study reveals two distinct subpopulations of arthritic mice with spontaneous arthritis due to deficiency for interleukin- 1 receptor antagonist, suggesting that genes with function relevant to myeloid cell and/or apoptotic activities are most likely the key candidate genes for the QTL.

Original languageEnglish (US)
Pages (from-to)107-113
Number of pages7
JournalGenes and Genetic Systems
Volume87
Issue number2
DOIs
StatePublished - Jan 1 2012

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Interleukin-1 Receptors
Genetic Association Studies
Arthritis
Quantitative Trait Loci
Myeloid Cells
Genes
Inbred DBA Mouse
Chromosomes, Human, Pair 1
Inflammation

All Science Journal Classification (ASJC) codes

  • Molecular Biology
  • Genetics

Cite this

Analysis of candidate genes of spontaneous arthritis inmice deficient for interleukin-1 receptor antagonist. / Cao, Yanhong; Li, Caijuan; Yan, Jian; Jiao, Feng; Liu, Xiao Yun; Hasty, Karen; Stuart, John; Gu, Weikuan; Jiao, Yan.

In: Genes and Genetic Systems, Vol. 87, No. 2, 01.01.2012, p. 107-113.

Research output: Contribution to journalArticle

Cao, Yanhong ; Li, Caijuan ; Yan, Jian ; Jiao, Feng ; Liu, Xiao Yun ; Hasty, Karen ; Stuart, John ; Gu, Weikuan ; Jiao, Yan. / Analysis of candidate genes of spontaneous arthritis inmice deficient for interleukin-1 receptor antagonist. In: Genes and Genetic Systems. 2012 ; Vol. 87, No. 2. pp. 107-113.
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