Analysis of post-deployment cognitive performance and symptom recovery in U.S. Marines

F. J. Haran, Aimee L. Alphonso, Alia Creason, Justin S. Campbell, Dagny Johnson, Emily Young, Jack Tsao

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Background: Computerized neurocognitive testing (NCAT) has been proposed to be useful as a screening tool for post-deployment cognitive deficits in the setting of mild traumatic brain injury (mTBI). We assessed the clinical utility of post-injury/ post-deployment Automated Neurocognitive Assessment Metric (ANAM) testing, using a longitudinal design to compare baseline ANAM tests with two post-deployment ANAM tests in a group of Marines who experienced combat during deployment. Methods and Findings: Post-deployment cognitive performance and symptom recovery were compared in a subsample of 1324 U.S. Marines with high rates of combat exposure during deployment. Of the sample, 169 Marines had available baseline and twice repeated post-deployment ANAM results. A retrospective analysis of the ANAM data, which consisted of a self-report questionnaire about deployment-related blast exposure, recent history of mTBI, current clinical symptoms, and cognitive performance. Self-reported concussion sustained anytime during deployment was associated with a decrease in cognitive performance measured between 2-8 weeks post-deployment. At the second post-deployment test conducted on average eight months later, performance on the second simple reaction time test, in particular, remained impaired and was the most consistent and sensitive indicator of the cognitive decrements. Additionally, post-concussive symptoms were shown to persist in injured Marines with a self-reported history of concussion for an additional five months after most cognitive deficits resolved. Results of this study showed a measurable deployment effect on cognitive performance, although this effect appears to resolve without lasting clinical sequelae in those without history of deployment-related concussion. Conclusions: These results highlight the need for a detailed clinical examination for service members with history of concussion and persistent clinical symptoms. Reliance solely upon computerized neurocognitive testing as a method for identifying service members requiring clinical follow-up post-concussion is not recommended, as cognitive functioning only slowly returned to baseline levels in the setting of persistent clinical symptoms.

Original languageEnglish (US)
Article numbere79595
JournalPloS one
Volume8
Issue number11
DOIs
StatePublished - Nov 27 2013

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Neurobehavioral Manifestations
Military Personnel
cognition
signs and symptoms (animals and humans)
Brain Concussion
Recovery
Brain
Testing
Post-Concussion Syndrome
testing
Screening
Self Report
brain
complications (disease)
Wounds and Injuries
clinical examination
questionnaires
screening
methodology

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)

Cite this

Haran, F. J., Alphonso, A. L., Creason, A., Campbell, J. S., Johnson, D., Young, E., & Tsao, J. (2013). Analysis of post-deployment cognitive performance and symptom recovery in U.S. Marines. PloS one, 8(11), [e79595]. https://doi.org/10.1371/journal.pone.0079595

Analysis of post-deployment cognitive performance and symptom recovery in U.S. Marines. / Haran, F. J.; Alphonso, Aimee L.; Creason, Alia; Campbell, Justin S.; Johnson, Dagny; Young, Emily; Tsao, Jack.

In: PloS one, Vol. 8, No. 11, e79595, 27.11.2013.

Research output: Contribution to journalArticle

Haran, FJ, Alphonso, AL, Creason, A, Campbell, JS, Johnson, D, Young, E & Tsao, J 2013, 'Analysis of post-deployment cognitive performance and symptom recovery in U.S. Marines', PloS one, vol. 8, no. 11, e79595. https://doi.org/10.1371/journal.pone.0079595
Haran FJ, Alphonso AL, Creason A, Campbell JS, Johnson D, Young E et al. Analysis of post-deployment cognitive performance and symptom recovery in U.S. Marines. PloS one. 2013 Nov 27;8(11). e79595. https://doi.org/10.1371/journal.pone.0079595
Haran, F. J. ; Alphonso, Aimee L. ; Creason, Alia ; Campbell, Justin S. ; Johnson, Dagny ; Young, Emily ; Tsao, Jack. / Analysis of post-deployment cognitive performance and symptom recovery in U.S. Marines. In: PloS one. 2013 ; Vol. 8, No. 11.
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