Analysis of prognostic features in adenocarcinoma of the cervix

Larry Kilgore, Seng Jaw Soong, Hazel Gore, Hugh M. Shingleton, Kenneth D. Hatch, Edward E. Partridge

Research output: Contribution to journalArticle

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Abstract

Uncertainties regarding the clinical behavior and management of women with primary adenocarcinoma of the cervix persist. A series of 162 patients was evaluated with emphasis on histopathology, clinical features, treatment, and survival. Sixty-seven patients underwent radical hysterectomy alone, 65 patients underwent radiation therapy alone, while the remainder were treated with combined surgery and radiotherapy. When compared to a matched series of squamous cell carcinoma patients, no statistical differences in survival could be demonstrated. Clinical stage (P < 0.001) and lesion size (P < 0.001) were the most important prognostic factors for the entire series. Patients with adenocarcinoma of varied histologic patterns were compared to patients with adenosquamous lesions and no statistical difference in survival could be demonstrated. Multivariate analysis of those women with Stage I adenocarcinoma of the cervix identified risk groups based on tumor grade, lesion size, and patient age. Patients in the low risk group had a 5-year survival of 89.5% while patients in the intermediate and high risk groups had 5-year survival rates of 68.4 and 37.3%. respectively. In patients with Stage I well-differentiated lesions survival was excellent, independent of lesion size.

Original languageEnglish (US)
Pages (from-to)137-148
Number of pages12
JournalGynecologic oncology
Volume31
Issue number1
DOIs
StatePublished - Jan 1 1988

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Cervix Uteri
Adenocarcinoma
Survival
Radiotherapy
Hysterectomy
Uncertainty
Squamous Cell Carcinoma
Multivariate Analysis
Survival Rate

All Science Journal Classification (ASJC) codes

  • Oncology
  • Obstetrics and Gynecology

Cite this

Kilgore, L., Soong, S. J., Gore, H., Shingleton, H. M., Hatch, K. D., & Partridge, E. E. (1988). Analysis of prognostic features in adenocarcinoma of the cervix. Gynecologic oncology, 31(1), 137-148. https://doi.org/10.1016/0090-8258(88)90281-8

Analysis of prognostic features in adenocarcinoma of the cervix. / Kilgore, Larry; Soong, Seng Jaw; Gore, Hazel; Shingleton, Hugh M.; Hatch, Kenneth D.; Partridge, Edward E.

In: Gynecologic oncology, Vol. 31, No. 1, 01.01.1988, p. 137-148.

Research output: Contribution to journalArticle

Kilgore, L, Soong, SJ, Gore, H, Shingleton, HM, Hatch, KD & Partridge, EE 1988, 'Analysis of prognostic features in adenocarcinoma of the cervix', Gynecologic oncology, vol. 31, no. 1, pp. 137-148. https://doi.org/10.1016/0090-8258(88)90281-8
Kilgore, Larry ; Soong, Seng Jaw ; Gore, Hazel ; Shingleton, Hugh M. ; Hatch, Kenneth D. ; Partridge, Edward E. / Analysis of prognostic features in adenocarcinoma of the cervix. In: Gynecologic oncology. 1988 ; Vol. 31, No. 1. pp. 137-148.
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