Analytical processing of binary mixture information by olfactory bulb glomeruli

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Odors are rarely composed of a single compound, but rather contain a large and complex variety of chemical components. Often, these mixtures are perceived as having unique qualities that can be quite different than the combination of their components. In many cases, a majority of the components of a mixture cannot be individually identified. This synthetic processing of odor information suggests that individual component representations of the mixture must interact somewhere along the olfactory pathway. The anatomical nature of sensory neuron input into segregated glomeruli with the bulb suggests that initial input of odor information into the bulb is analytic. However, a large network of interneurons within the olfactory bulb could allow for mixture interactions via mechanisms such as lateral inhibition. Currently in mammals, it is unclear if postsynaptic mitral/tufted cell glomerular mixture responses reflect the analytical mixture input, or provide the initial basis for synthetic processing with the olfactory system. To address this, olfactory bulb glomerular binary mixture representations were compared to representations of each component using transgenic mice expressing the calcium indicator G-CaMP2 in olfactory bulb mitral/tufted cells. Overall, dorsal surface mixture representations showed little mixture interaction and often appeared as a simple combination of the component representations. Based on this, it is concluded that dorsal surface glomerular mixture representations remain largely analytical with nearly all component information preserved.

Original languageEnglish (US)
Article numbere29360
JournalPloS one
Volume6
Issue number12
DOIs
StatePublished - Nov 20 2011

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olfactory bulb
Olfactory Bulb
Binary mixtures
Processing
Olfactory Pathways
Odors
Interneurons
Sensory Receptor Cells
Automatic Data Processing
Transgenic Mice
Mammals
Calcium
odors
bulbs
Odorants
sensory neurons
interneurons
Neurons
genetically modified organisms
cells

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)

Cite this

Analytical processing of binary mixture information by olfactory bulb glomeruli. / Fletcher, Max.

In: PloS one, Vol. 6, No. 12, e29360, 20.11.2011.

Research output: Contribution to journalArticle

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