Ancestry and pharmacogenomics of relapse in acute lymphoblastic leukemia

Jun J. Yang, Cheng Cheng, Meenakshi Devidas, Xueyuan Cao, Yiping Fan, Dario Campana, Wenjian Yang, Geoff Neale, Nancy J. Cox, Paul Scheet, Michael J. Borowitz, Naomi J. Winick, Paul L. Martin, Cheryl L. Willman, W. Paul Bowman, Bruce M. Camitta, Andrew Carroll, Gregory H. Reaman, William L. Carroll, Mignon Loh & 4 others Stephen P. Hunger, Ching Hon Pui, William E. Evans, Mary V. Relling

Research output: Contribution to journalReview article

156 Citations (Scopus)

Abstract

Although five-year survival rates for childhood acute lymphoblastic leukemia (ALL) are now over 80% in most industrialized countries1, not all children have benefited equally from this progress2. Ethnic differences in survival after childhood ALL have been reported in many clinical studies3-11, with poorer survival observed among African Americans or those with Hispanic ethnicity when compared with European Americans or Asians3-5. The causes of ethnic differences remain uncertain, although both genetic and non-genetic factors are likely important 4,12. Interrogating genome-wide germline SNP genotypes in an unselected large cohort of children with ALL, we observed that the component of genomic variation that co-segregated with Native American ancestry was associated with risk of relapse (P = 0.0029) even after adjusting for known prognostic factors (P = 0.017). Ancestry-related differences in relapse risk were abrogated by the addition of a single extra phase of chemotherapy, indicating that modifications to therapy can mitigate the ancestry-related risk of relapse.

Original languageEnglish (US)
Pages (from-to)237-241
Number of pages5
JournalNature Genetics
Volume43
Issue number3
DOIs
StatePublished - Mar 1 2011

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Pharmacogenetics
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Recurrence
North American Indians
Hispanic Americans
African Americans
Single Nucleotide Polymorphism
Survival Rate
Genotype
Genome
Drug Therapy
Therapeutics

All Science Journal Classification (ASJC) codes

  • Genetics

Cite this

Yang, J. J., Cheng, C., Devidas, M., Cao, X., Fan, Y., Campana, D., ... Relling, M. V. (2011). Ancestry and pharmacogenomics of relapse in acute lymphoblastic leukemia. Nature Genetics, 43(3), 237-241. https://doi.org/10.1038/ng.763

Ancestry and pharmacogenomics of relapse in acute lymphoblastic leukemia. / Yang, Jun J.; Cheng, Cheng; Devidas, Meenakshi; Cao, Xueyuan; Fan, Yiping; Campana, Dario; Yang, Wenjian; Neale, Geoff; Cox, Nancy J.; Scheet, Paul; Borowitz, Michael J.; Winick, Naomi J.; Martin, Paul L.; Willman, Cheryl L.; Bowman, W. Paul; Camitta, Bruce M.; Carroll, Andrew; Reaman, Gregory H.; Carroll, William L.; Loh, Mignon; Hunger, Stephen P.; Pui, Ching Hon; Evans, William E.; Relling, Mary V.

In: Nature Genetics, Vol. 43, No. 3, 01.03.2011, p. 237-241.

Research output: Contribution to journalReview article

Yang, JJ, Cheng, C, Devidas, M, Cao, X, Fan, Y, Campana, D, Yang, W, Neale, G, Cox, NJ, Scheet, P, Borowitz, MJ, Winick, NJ, Martin, PL, Willman, CL, Bowman, WP, Camitta, BM, Carroll, A, Reaman, GH, Carroll, WL, Loh, M, Hunger, SP, Pui, CH, Evans, WE & Relling, MV 2011, 'Ancestry and pharmacogenomics of relapse in acute lymphoblastic leukemia', Nature Genetics, vol. 43, no. 3, pp. 237-241. https://doi.org/10.1038/ng.763
Yang JJ, Cheng C, Devidas M, Cao X, Fan Y, Campana D et al. Ancestry and pharmacogenomics of relapse in acute lymphoblastic leukemia. Nature Genetics. 2011 Mar 1;43(3):237-241. https://doi.org/10.1038/ng.763
Yang, Jun J. ; Cheng, Cheng ; Devidas, Meenakshi ; Cao, Xueyuan ; Fan, Yiping ; Campana, Dario ; Yang, Wenjian ; Neale, Geoff ; Cox, Nancy J. ; Scheet, Paul ; Borowitz, Michael J. ; Winick, Naomi J. ; Martin, Paul L. ; Willman, Cheryl L. ; Bowman, W. Paul ; Camitta, Bruce M. ; Carroll, Andrew ; Reaman, Gregory H. ; Carroll, William L. ; Loh, Mignon ; Hunger, Stephen P. ; Pui, Ching Hon ; Evans, William E. ; Relling, Mary V. / Ancestry and pharmacogenomics of relapse in acute lymphoblastic leukemia. In: Nature Genetics. 2011 ; Vol. 43, No. 3. pp. 237-241.
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AU - Reaman, Gregory H.

AU - Carroll, William L.

AU - Loh, Mignon

AU - Hunger, Stephen P.

AU - Pui, Ching Hon

AU - Evans, William E.

AU - Relling, Mary V.

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