Anemia in macroglobulinemia

Martin J. Cline, Alan Solomon, Nathaniel I. Berlin, John L. Fahey

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Erythrokinetic and red cell survival studies were performed in ten patients with macroglobulinemia. Inadequate red cell synthesis, decreased erythrocyte survival and iron deficiency, alone or in combination, were responsible for anemia in eight of these patients. In six patients there was a relative failure of red cell production with inadequate compensation for excessive red cell destruction. In two patients there was an absolute failure of erythropoiesis with functional aplasia. No simple correlation between rate of erythropoiesis and serum gamma macroglobulin concentration was evident. Shortened erythrocyte life span was found in eight of the ten patients and was most prominent in those with active disease. Serial studies before and after plasmapheresis in two patients showed that reduction of serum viscosity and macroglobulin level was associated with increased red cell survival. Causes of shortened erythrocyte survival included bleeding disorders, Coombs' positive hemolytic anemia and erythrocyte sequestration by the spleen. Two patients had advanced iron deficiency and four had evidence of early iron deficiency. Depletion of body iron stores usually could be related to external blood loss. The typical features of iron depletion were present when iron deficiency was advanced. Therapy of anemia in these patients consisted of plasmapheresis with or without chemotherapy for disease manifestations associated with high serum viscosity, corticosteroids when immune hemolysis was demonstrable, and iron for iron deficiency.

Original languageEnglish (US)
Pages (from-to)213-220
Number of pages8
JournalThe American Journal of Medicine
Volume34
Issue number2
DOIs
StatePublished - Jan 1 1963
Externally publishedYes

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Waldenstrom Macroglobulinemia
Anemia
Iron
Erythrocyte Aging
Macroglobulins
Plasmapheresis
Erythropoiesis
Viscosity
Cell Survival
Erythrocytes
Serum
Hemolytic Anemia
Hemolysis
Adrenal Cortex Hormones
Spleen
Hemorrhage
Drug Therapy

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

Anemia in macroglobulinemia. / Cline, Martin J.; Solomon, Alan; Berlin, Nathaniel I.; Fahey, John L.

In: The American Journal of Medicine, Vol. 34, No. 2, 01.01.1963, p. 213-220.

Research output: Contribution to journalArticle

Cline, Martin J. ; Solomon, Alan ; Berlin, Nathaniel I. ; Fahey, John L. / Anemia in macroglobulinemia. In: The American Journal of Medicine. 1963 ; Vol. 34, No. 2. pp. 213-220.
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