Anesthetic diffusion through lipid membranes depends on the protonation rate

Rosendo Pérez-Isidoro, Francisco Sierra Valdez, J. C. Ruiz-Suárez

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Hundreds of substances possess anesthetic action. However, despite decades of research and tests, a golden rule is required to reconcile the diverse hypothesis behind anesthesia. What makes an anesthetic to be local or general in the first place? The specific targets on proteins, the solubility in lipids, the diffusivity, potency, action time? Here we show that there could be a new player equally or even more important to disentangle the riddle: the protonation rate. Indeed, such rate modulates the diffusion speed of anesthetics into lipid membranes; low protonation rates enhance the diffusion for local anesthetics while high ones reduce it. We show also that there is a pH and membrane phase dependence on the local anesthetic diffusion across multiple lipid bilayers. Based on our findings we incorporate a new clue that may advance our understanding of the anesthetic phenomenon.

Original languageEnglish (US)
JournalScientific Reports
Volume4
DOIs
StatePublished - Dec 18 2014

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Membrane Lipids
Anesthetics
Local Anesthetics
Lipid Bilayers
Solubility
Anesthesia
Lipids
Membranes
Research
Proteins

All Science Journal Classification (ASJC) codes

  • General

Cite this

Anesthetic diffusion through lipid membranes depends on the protonation rate. / Pérez-Isidoro, Rosendo; Sierra Valdez, Francisco; Ruiz-Suárez, J. C.

In: Scientific Reports, Vol. 4, 18.12.2014.

Research output: Contribution to journalArticle

Pérez-Isidoro, Rosendo ; Sierra Valdez, Francisco ; Ruiz-Suárez, J. C. / Anesthetic diffusion through lipid membranes depends on the protonation rate. In: Scientific Reports. 2014 ; Vol. 4.
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