Angiogenesis model of cornea to understand the role of sphingosine 1-phosphate

Joseph L. Wilkerson, Nawajes Mandal

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Citation (Scopus)

Abstract

The role of sphingolipids, mainly sphingosine 1-phosphate (S1P) and the receptors for which it serves as a ligand, is an interesting and promising area in both sphingolipid and vascular biology. S1P is crucial for establishing blood flow competent blood vessels (Jung et al. Dev Cell 23(3):600–610, 2012). The role of S1P in neovascular pathology is of great interest and promising as a target for treatment. Here we describe an easy and affordable in vivo model of neovascularization by an alkali chemical burn to the cornea. This gives a consistent and easy way to quantitate methods for neovascularization.

Original languageEnglish (US)
Title of host publicationMethods in Molecular Biology
PublisherHumana Press Inc.
Pages267-276
Number of pages10
DOIs
StatePublished - Jan 1 2017

Publication series

NameMethods in Molecular Biology
Volume1609
ISSN (Print)1064-3745

Fingerprint

Sphingolipids
Cornea
Blood Vessels
Chemical Burns
Lysosphingolipid Receptors
Alkalies
Pathology
Ligands
sphingosine 1-phosphate

All Science Journal Classification (ASJC) codes

  • Molecular Biology
  • Genetics

Cite this

Wilkerson, J. L., & Mandal, N. (2017). Angiogenesis model of cornea to understand the role of sphingosine 1-phosphate. In Methods in Molecular Biology (pp. 267-276). (Methods in Molecular Biology; Vol. 1609). Humana Press Inc.. https://doi.org/10.1007/978-1-4939-6996-8_23

Angiogenesis model of cornea to understand the role of sphingosine 1-phosphate. / Wilkerson, Joseph L.; Mandal, Nawajes.

Methods in Molecular Biology. Humana Press Inc., 2017. p. 267-276 (Methods in Molecular Biology; Vol. 1609).

Research output: Chapter in Book/Report/Conference proceedingChapter

Wilkerson, JL & Mandal, N 2017, Angiogenesis model of cornea to understand the role of sphingosine 1-phosphate. in Methods in Molecular Biology. Methods in Molecular Biology, vol. 1609, Humana Press Inc., pp. 267-276. https://doi.org/10.1007/978-1-4939-6996-8_23
Wilkerson JL, Mandal N. Angiogenesis model of cornea to understand the role of sphingosine 1-phosphate. In Methods in Molecular Biology. Humana Press Inc. 2017. p. 267-276. (Methods in Molecular Biology). https://doi.org/10.1007/978-1-4939-6996-8_23
Wilkerson, Joseph L. ; Mandal, Nawajes. / Angiogenesis model of cornea to understand the role of sphingosine 1-phosphate. Methods in Molecular Biology. Humana Press Inc., 2017. pp. 267-276 (Methods in Molecular Biology).
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