Angiotensin 1-7 promotes cardiac angiogenesis following infarction

Wenyuan Zhao, Tieqiang Zhao, Yuanjian Chen, Yao Sun

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Angiogenesis is central to cardiac repair following myocardial infarction (MI). Cardiac angiotensin converting enzyme (ACE)2 significantly increased postMI, which is coincident with activated angiogenesis. The function of ACE2 is to generate angiotensin (Ang)1-7, an active peptide with cellular actions mediated by Mas receptors. The current study is to determine whether Ang(1-7) is involved in cardiac angiogenesis and facilitates cardiac repair. In the first portion of the study, the temporal expressions of cardiac ACE2 and Mas receptors were detected in rats with MI. In the second portion, MI rats were treated with or without a Mas receptor antagonist, A779 (1mg/kg/day given by minipump) for 7 days. Vascular density and expression of angiogenic mediators in the infarcted myocardium and cardiac function were examined. Compared to controls, ACE2 and Mas receptor levels were significantly increased in the infarcted myocardium for 4 weeks of the observation period. Newly formed vessels were evident in the infarcted myocardium at day 7. Mas receptor blockade significantly reduced vascular density in the infarcted myocardium and impaired ventricular function. In addition, A779 treatment significantly suppressed the cardiac expressions of vascular endothelial growth factor (VEGF)-D and matrix metalloproteinase (MMP)-9 but not expression of other angiogenic mediators, including monocyte Chemoattractant protein (MCP-1), VEGF-C, transforming growth factor (TGF)-β1 and integrin β3. These observations indicate that Ang(1-7) promotes angiogenesis via stimulating the expression of cardiac VEGF-D and MMP-9, thus facilitating cardiac repair and ventricular function.

Original languageEnglish (US)
Pages (from-to)37-42
Number of pages6
JournalCurrent Vascular Pharmacology
Volume13
Issue number1
DOIs
StatePublished - Jan 1 2015

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Infarction
7-Ala-angiotensin (1-7)
Myocardium
Vascular Endothelial Growth Factor D
Ventricular Function
Myocardial Infarction
Matrix Metalloproteinase 9
Blood Vessels
Vascular Endothelial Growth Factor C
Chemokine CCL2
Transforming Growth Factors
Integrins
Observation
Peptides
angiotensin I (1-7)

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Cardiology and Cardiovascular Medicine

Cite this

Angiotensin 1-7 promotes cardiac angiogenesis following infarction. / Zhao, Wenyuan; Zhao, Tieqiang; Chen, Yuanjian; Sun, Yao.

In: Current Vascular Pharmacology, Vol. 13, No. 1, 01.01.2015, p. 37-42.

Research output: Contribution to journalArticle

Zhao, Wenyuan ; Zhao, Tieqiang ; Chen, Yuanjian ; Sun, Yao. / Angiotensin 1-7 promotes cardiac angiogenesis following infarction. In: Current Vascular Pharmacology. 2015 ; Vol. 13, No. 1. pp. 37-42.
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