Angiotensin converting enzyme inhibition in heart, kidney, and serum studied ex vivo after administration of zofenopril, captopril, and lisinopril

Yao Sun, Frederick A.O. Mendelsohn

Research output: Contribution to journalArticle

54 Citations (Scopus)

Abstract

Angiotensin converting enzyme inhibition in heart, kidney, and serum were studied ex vivo after oral administration of lisinopril (10 mg/kg), zofenopril (10 mg/kg), and captopril (30 mg/kg) to rats to study the time course, degree, and sites of inhibition of ACE by a quantitative in vitro autoradiography and enzymatic assay. ACE activity in all regions of the heart, kidney, and se-rum was markedly reduced 4 h after administration of lisinopril and zofenopril and only partially recovered toward control levels at 24 h. After captopril treatment, ACE activity was partially inhibited in heart, kidney, and serum at 1 h and fully recovered toward control levels in most regions at 24 h. These results suggest that these inhibitors reduce ACE in all regions of the heart and kidney without regional selective inhibition. Lisinopril and zofenopril at these doses produced longer-lasting ACE inhibition than captopril. ACE recovery after ACE inhibitor treatment in serum was faster than in heart or kidney.

Original languageEnglish (US)
Pages (from-to)478-486
Number of pages9
JournalJournal of Cardiovascular Pharmacology
Volume18
Issue number4
DOIs
StatePublished - Jan 1 1991
Externally publishedYes

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zofenopril
Lisinopril
Captopril
Peptidyl-Dipeptidase A
Kidney
Serum
Angiotensin-Converting Enzyme Inhibitors
Enzyme Assays
Autoradiography
Oral Administration

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Cardiology and Cardiovascular Medicine

Cite this

Angiotensin converting enzyme inhibition in heart, kidney, and serum studied ex vivo after administration of zofenopril, captopril, and lisinopril. / Sun, Yao; Mendelsohn, Frederick A.O.

In: Journal of Cardiovascular Pharmacology, Vol. 18, No. 4, 01.01.1991, p. 478-486.

Research output: Contribution to journalArticle

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