Angiotensin II and extracellular matrix homeostasis

Karl Weber, S. K. Swamynathan, Ramareddy Guntaka, Yao Sun

Research output: Contribution to journalShort survey

61 Citations (Scopus)

Abstract

As a circulating hormone, endocrine properties of angiotensin (Ang) II are integral to circulatory homeostasis. Produced de novo its autocrine/paracrine properties contribute to biologic responses involving various connective tissues (e.g. extracellular matrix, adipose tissue, bone and its marrow). In this brief review, we develop the concept of extracellular matrix homeostasis, a self regulation of cellular composition and structure, wherein fibroblast-derived AngII regulates elaboration of TGF-β1, a fibrogenic cytokine responsible for connective tissue formation at normal and pathologic sites of collagen turnover. Copyright (C) 1999 Elsevier Science Ltd.

Original languageEnglish (US)
Pages (from-to)395-403
Number of pages9
JournalInternational Journal of Biochemistry and Cell Biology
Volume31
Issue number3-4
DOIs
StatePublished - Jan 1 1999
Externally publishedYes

Fingerprint

Angiotensin II
Connective Tissue
Extracellular Matrix
Homeostasis
Tissue
Cellular Structures
Adipose Tissue
Collagen
Fibroblasts
Bone Marrow
Hormones
Cytokines
Bone
Chemical analysis

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Cell Biology

Cite this

Angiotensin II and extracellular matrix homeostasis. / Weber, Karl; Swamynathan, S. K.; Guntaka, Ramareddy; Sun, Yao.

In: International Journal of Biochemistry and Cell Biology, Vol. 31, No. 3-4, 01.01.1999, p. 395-403.

Research output: Contribution to journalShort survey

@article{b79397b51da04c788c8df6424aa936fe,
title = "Angiotensin II and extracellular matrix homeostasis",
abstract = "As a circulating hormone, endocrine properties of angiotensin (Ang) II are integral to circulatory homeostasis. Produced de novo its autocrine/paracrine properties contribute to biologic responses involving various connective tissues (e.g. extracellular matrix, adipose tissue, bone and its marrow). In this brief review, we develop the concept of extracellular matrix homeostasis, a self regulation of cellular composition and structure, wherein fibroblast-derived AngII regulates elaboration of TGF-β1, a fibrogenic cytokine responsible for connective tissue formation at normal and pathologic sites of collagen turnover. Copyright (C) 1999 Elsevier Science Ltd.",
author = "Karl Weber and Swamynathan, {S. K.} and Ramareddy Guntaka and Yao Sun",
year = "1999",
month = "1",
day = "1",
doi = "10.1016/S1357-2725(98)00125-3",
language = "English (US)",
volume = "31",
pages = "395--403",
journal = "International Journal of Biochemistry and Cell Biology",
issn = "1357-2725",
publisher = "Elsevier Limited",
number = "3-4",

}

TY - JOUR

T1 - Angiotensin II and extracellular matrix homeostasis

AU - Weber, Karl

AU - Swamynathan, S. K.

AU - Guntaka, Ramareddy

AU - Sun, Yao

PY - 1999/1/1

Y1 - 1999/1/1

N2 - As a circulating hormone, endocrine properties of angiotensin (Ang) II are integral to circulatory homeostasis. Produced de novo its autocrine/paracrine properties contribute to biologic responses involving various connective tissues (e.g. extracellular matrix, adipose tissue, bone and its marrow). In this brief review, we develop the concept of extracellular matrix homeostasis, a self regulation of cellular composition and structure, wherein fibroblast-derived AngII regulates elaboration of TGF-β1, a fibrogenic cytokine responsible for connective tissue formation at normal and pathologic sites of collagen turnover. Copyright (C) 1999 Elsevier Science Ltd.

AB - As a circulating hormone, endocrine properties of angiotensin (Ang) II are integral to circulatory homeostasis. Produced de novo its autocrine/paracrine properties contribute to biologic responses involving various connective tissues (e.g. extracellular matrix, adipose tissue, bone and its marrow). In this brief review, we develop the concept of extracellular matrix homeostasis, a self regulation of cellular composition and structure, wherein fibroblast-derived AngII regulates elaboration of TGF-β1, a fibrogenic cytokine responsible for connective tissue formation at normal and pathologic sites of collagen turnover. Copyright (C) 1999 Elsevier Science Ltd.

UR - http://www.scopus.com/inward/record.url?scp=0032993021&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0032993021&partnerID=8YFLogxK

U2 - 10.1016/S1357-2725(98)00125-3

DO - 10.1016/S1357-2725(98)00125-3

M3 - Short survey

VL - 31

SP - 395

EP - 403

JO - International Journal of Biochemistry and Cell Biology

JF - International Journal of Biochemistry and Cell Biology

SN - 1357-2725

IS - 3-4

ER -