Angiotensin type 1 receptor A1166C polymorphism and systemic lupus erythematosus

correlation with cellular immunity and oxidative stress markers

H. Baniamerian, F. Bahrehmand, A. Vaisi-Raygani, Z. Rahimi, Tayebeh Pourmotabbed

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Angiotensin II, one of the rennin–angiotensin system components, is important in the cardiovascular hemodynamic and plays an important role in the development of cardiovascular disease in systemic lupus erythematosus (SLE) patients. The angiotensin II, through interaction with angiotensin II type 1 receptor (AGTR1), promotes proliferation, inflammation and fibrosis. The single nucleotide polymorphism of the AGTR1 (dbSNP: rs5186) gene can be associated with development and progression of SLE disease. The aims of this study were to compare the frequency of AGTR1 rs5186 in SLE patients with healthy individuals and to evaluate possible association between AGTR1 A1166C gene polymorphism and serum level of lipids, neopterin and malondialdehyde in SLE patients from a population of West Iran. One hundred SLE patients and 98 healthy subjects were studied. The AGTR1 A1166C polymorphism was detected by polymerase chain reaction–restriction fragment length polymorphism method and the serum lipid profile was obtained by enzymatic method. Neopterin and malondialdehyde were detected using high-performance liquid chromatography. We did not detect significant association between AGTR1 A1166C polymorphism and the risk of SLE. The levels of triglyceride (225 ± 118 mg/dl), neopterin (30 ± 24 nmol/l) and malondialdehyde (25 ± 9.6 nmol/l) in SLE patients were significantly higher than those in control subjects (139 ± 56 mg/dl, p = 0.03, 6.4 ± 2, p = 0.03, 9.4 ± 2.5 nmol/l, p = 0.01, respectively). Individuals with AGTR1 AC + CC genotype had higher levels of total cholesterol and malondialdehyde compared with those with AGTR1 AA genotype. SLE patients with either AGTR1 AA or AGTR1AC + CC genotype had significantly higher malondialdehyde or neopterin levels compared with the corresponding control subjects. In conclusion, although the present study did not find any association between AGTR1 A1166C polymorphism and the risk of SLE, the presence of this polymorphism was associated with higher levels of malondialdehyde and higher concentration of neopterin in patients.

Original languageEnglish (US)
Pages (from-to)1534-1539
Number of pages6
JournalLupus
Volume26
Issue number14
DOIs
StatePublished - Dec 1 2017

Fingerprint

Angiotensin Type 1 Receptor
Cellular Immunity
Systemic Lupus Erythematosus
Oxidative Stress
Neopterin
Malondialdehyde
Genotype
Angiotensin II
Lipids
Iran
Hypercholesterolemia
Serum
Genes
Single Nucleotide Polymorphism
Healthy Volunteers
Triglycerides
Fibrosis
Cardiovascular Diseases
Hemodynamics
High Pressure Liquid Chromatography

All Science Journal Classification (ASJC) codes

  • Rheumatology

Cite this

Angiotensin type 1 receptor A1166C polymorphism and systemic lupus erythematosus : correlation with cellular immunity and oxidative stress markers. / Baniamerian, H.; Bahrehmand, F.; Vaisi-Raygani, A.; Rahimi, Z.; Pourmotabbed, Tayebeh.

In: Lupus, Vol. 26, No. 14, 01.12.2017, p. 1534-1539.

Research output: Contribution to journalArticle

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