Animal models in biomedical research: Ethics, challenges, and opportunities

Research output: Chapter in Book/Report/Conference proceedingChapter

3 Citations (Scopus)

Abstract

Diagnostic power needs to be matched to prognostic accuracy. To accomplish this, we need robust animal models that incorporate the same level of genetic and genomic variation as highly diverse human populations. A key goal of biomedical research is to provide clinicians with sufficient knowledge to predict disease risk and choose effective treatment. We are on the cusp of having complete genome data for each patient. However, our current understanding of complex biological systems and individual differences does not allow us to predict effects of novel interventions and drugs. Animal models provide precise genetic and experimental control, and they also provide a route to more rapid discovery and validation of disease prevention and treatment. But the successful application of experimental results to diverse humans requires that models accurately represent both the underlying disease process and the impact of human genetic variation on treatment and outcome.

Original languageEnglish (US)
Title of host publicationPrinciples of Molecular Medicine
PublisherHumana Press
Pages53-60
Number of pages8
ISBN (Print)9781588292025
DOIs
StatePublished - Dec 1 2006

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Research Ethics
Bioethics
Biomedical Research
Animal Models
Medical Genetics
Individuality
Genome
Therapeutics
Pharmaceutical Preparations
Population

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

Animal models in biomedical research : Ethics, challenges, and opportunities. / Williams, Robert.

Principles of Molecular Medicine. Humana Press, 2006. p. 53-60.

Research output: Chapter in Book/Report/Conference proceedingChapter

Williams, Robert. / Animal models in biomedical research : Ethics, challenges, and opportunities. Principles of Molecular Medicine. Humana Press, 2006. pp. 53-60
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