Anisotropic mechanosensitive pathways in the diaphragm and their implications in muscular dystrophies

Patricia S. Pardo, Michael A. Lopez, Junaith Mohamed, Aladin M. Boriek

Research output: Contribution to journalReview article

Abstract

The diaphragm is the “respiratory pump;” the muscle that generates pressure to allow ventilation. Diaphragm muscles play a vital function and thus are subjected to continuous mechanical loading. One of its peculiarities is the ability to generate distinct mechanical and biochemical responses depending on the direction through which the mechanical forces applied to it. Contractile forces originated from its contractile components are transmitted to other structural components of its muscle fibers and the surrounding connective tissue. The anisotropic mechanical properties of the diaphragm are translated into biochemical signals that are directionally mechanosensitive by mechanisms that appear to be unique to this muscle. Here, we reviewed the current state of knowledge on the biochemical pathways regulated by mechanical signals emphasizing their anisotropic behavior in the normal diaphragm and analyzed how they are affected in muscular dystrophies.

Original languageEnglish (US)
Pages (from-to)437-446
Number of pages10
JournalJournal of Muscle Research and Cell Motility
Volume38
Issue number5-6
DOIs
StatePublished - Dec 1 2017

Fingerprint

Muscular Dystrophies
Diaphragms
Diaphragm
Muscle
Muscles
Connective Tissue
Ventilation
Pumps
Tissue
Pressure
Mechanical properties
Fibers

All Science Journal Classification (ASJC) codes

  • Physiology
  • Biochemistry
  • Cell Biology

Cite this

Anisotropic mechanosensitive pathways in the diaphragm and their implications in muscular dystrophies. / Pardo, Patricia S.; Lopez, Michael A.; Mohamed, Junaith; Boriek, Aladin M.

In: Journal of Muscle Research and Cell Motility, Vol. 38, No. 5-6, 01.12.2017, p. 437-446.

Research output: Contribution to journalReview article

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