Annexins and Ca2+ handling in the heart

Emmanuel Camors, Virginie Monceau, Daniéle Charlemagne

Research output: Contribution to journalReview article

66 Citations (Scopus)

Abstract

Annexins are a family of 13 proteins known to bind phospholipids (PL) in a Ca2+-dependent way. They are ubiquitous proteins and share a similar structure characterized by a conserved C-terminal domain with Ca2+ binding sites and a variable N-terminal domain. Depending on Ca2+ concentration, they have been reported to participate in a variety of membrane-related events such as exocytosis, endocytosis, apoptosis and binding to cytoskeletal proteins. They have also been reported to regulate protein activities. This review will focus on annexins in the heart, and particularly on annexins A2, A5, A6 and A7. Annexin A2 has been found in endothelial cells and reported to play a central role in control of plasmin-mediated processes. Annexin A5 is mainly localized in cardiomyocytes. However, it could be relocated to interstitial tissue in ischemic and failing hearts or it could be externalized and exhibit a proapoptotic effect in cardiomyocytes. Annexin A6 is the most abundant annexin in the heart, and has been localized in various cell types including myocytes. Overexpression of annexin A6 has underlined physiological alterations in contractile mechanics leading to dilated cardiomyopathy, whereas knockout has been found to induce faster changes in Ca2+ transient and increased contractility, suggesting a negative inotropic role for annexin A6. Annexin A7 is expressed in heart and skeletal muscle. In annexin A7 null mutant mice decreases in the force-frequency relationship were observed in adult cardiomyocytes, consistent with regulation of Ca2+ handling. In conclusion, while annexin A2 was involved in regulation of fibrin homeostasis, alterations in expression and activity of annexins A5, A6 and A7 have been associated with regulation of Ca2+ handling in the heart, but the target of each annexin has not yet been identified.

Original languageEnglish (US)
Pages (from-to)793-802
Number of pages10
JournalCardiovascular research
Volume65
Issue number4
DOIs
StatePublished - Mar 1 2005

Fingerprint

Annexin A7
Annexin A6
Annexins
Annexin A2
Annexin A5
Cardiac Myocytes
Proteins
Cytoskeletal Proteins
Fibrinolysin
Exocytosis
Dilated Cardiomyopathy
Endocytosis
Mechanics
Fibrin
Muscle Cells
Phospholipids
Myocardium
Skeletal Muscle
Homeostasis
Endothelial Cells

All Science Journal Classification (ASJC) codes

  • Physiology
  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)

Cite this

Annexins and Ca2+ handling in the heart. / Camors, Emmanuel; Monceau, Virginie; Charlemagne, Daniéle.

In: Cardiovascular research, Vol. 65, No. 4, 01.03.2005, p. 793-802.

Research output: Contribution to journalReview article

Camors, Emmanuel ; Monceau, Virginie ; Charlemagne, Daniéle. / Annexins and Ca2+ handling in the heart. In: Cardiovascular research. 2005 ; Vol. 65, No. 4. pp. 793-802.
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