Anti-androgen-independent prostate cancer effects of ginsenoside metabolites in Vitro

Mechanism and possible structure-activity relationship investigation

Wei Li, Yong Liu, Jiang Wei Zhang, Chun Zhi Ai, Nan Xiang, Hui Xin Liu, Ling Yang

Research output: Contribution to journalArticle

35 Citations (Scopus)

Abstract

Treatment of androgen-independent prostate cancer (AIPC) remains unsatisfactory. In our present experiment, natural occurring ginsenosides (NOGs) and intestinal bacterial metabolites (IBMs) were employed to investigate their anti-AIPC cell growth activity using PC-3 cells. Our results showed that the IBMs exerted more portent anti-AIPC activity than NOGs, by decreasing survival rate, inhibiting proliferation, inducing apoptosis, and leading to cell cycle arrest in AIPC PC-3 cells. The increase of LogP and decrease of C-6 steric hindrance, which were caused by deglycosylation by intestinal bacteria, may be the reason for the higher anti-AIPC activity of IBMs.

Original languageEnglish (US)
Pages (from-to)49-57
Number of pages9
JournalArchives of Pharmacal Research
Volume32
Issue number1
DOIs
StatePublished - Jan 1 2009

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Ginsenosides
Structure-Activity Relationship
Metabolites
Androgens
Prostatic Neoplasms
Cell growth
Cell Cycle Checkpoints
Bacteria
Cells
In Vitro Techniques
Apoptosis
Growth
Experiments

All Science Journal Classification (ASJC) codes

  • Molecular Medicine
  • Drug Discovery
  • Organic Chemistry

Cite this

Anti-androgen-independent prostate cancer effects of ginsenoside metabolites in Vitro : Mechanism and possible structure-activity relationship investigation. / Li, Wei; Liu, Yong; Zhang, Jiang Wei; Ai, Chun Zhi; Xiang, Nan; Liu, Hui Xin; Yang, Ling.

In: Archives of Pharmacal Research, Vol. 32, No. 1, 01.01.2009, p. 49-57.

Research output: Contribution to journalArticle

Li, Wei ; Liu, Yong ; Zhang, Jiang Wei ; Ai, Chun Zhi ; Xiang, Nan ; Liu, Hui Xin ; Yang, Ling. / Anti-androgen-independent prostate cancer effects of ginsenoside metabolites in Vitro : Mechanism and possible structure-activity relationship investigation. In: Archives of Pharmacal Research. 2009 ; Vol. 32, No. 1. pp. 49-57.
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