Anti-ischemic effect of curcumin in rat brain

Pradeep Kumar Shukla, Vinay K. Khanna, Mohd M. Ali, Mohd Y. Khan, Rikhab C. Srimal

Research output: Contribution to journalArticle

107 Citations (Scopus)

Abstract

Turmeric has been in use since ancient times as a condiment and due to its medicinal properties. Curcumin, the yellow colouring principle in turmeric, is polyphenolic and major active constituent. Besides anti-inflammatory, thrombolytic and anticarcinogenic activities, curcumin also possesses strong antioxidant property. In view of the novel combination of properties, neuroprotective efficacy of curcumin was studied in rat middle cerebral artery occlusion (MCAO) model. Rats were subjected to 2 h of focal ischemia followed by 72 h of reperfusion. They were pre-treated with curcumin (100 mg/kg, po) for 5 days prior to MCAO and for another 3 days after MCAO. The parameters studied were behavioural, biochemical and histological. Treatment with curcumin could significantly improve neurobehavioral performance compared to untreated ischemic rats as judged by its effect on rota-rod performance and grid walking. A significant inhibition in lipid peroxidation and an increase in superoxide dismutase (SOD) activity in corpus striatum and cerebral cortex was observed following treatment with curcumin in MCAO rats as compared to MCAO group. Intracellular calcium levels were decreased following treatment with curcumin in MCAO rats. Histologically, a reduction in the infarct area from 33% to 24% was observed in MCAO rats treated with curcumin. The study demonstrates the protective efficacy of curcumin in rat MCAO model.

Original languageEnglish (US)
Pages (from-to)1036-1043
Number of pages8
JournalNeurochemical Research
Volume33
Issue number6
DOIs
StatePublished - Jun 1 2008
Externally publishedYes

Fingerprint

Curcumin
Middle Cerebral Artery Infarction
Rats
Brain
Curcuma
Condiments
Corpus Striatum
Coloring
Cerebral Cortex
Lipid Peroxidation
Superoxide Dismutase
Walking
Reperfusion
Anti-Inflammatory Agents
Ischemia
Antioxidants
Calcium
Lipids

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Cellular and Molecular Neuroscience

Cite this

Shukla, P. K., Khanna, V. K., Ali, M. M., Khan, M. Y., & Srimal, R. C. (2008). Anti-ischemic effect of curcumin in rat brain. Neurochemical Research, 33(6), 1036-1043. https://doi.org/10.1007/s11064-007-9547-y

Anti-ischemic effect of curcumin in rat brain. / Shukla, Pradeep Kumar; Khanna, Vinay K.; Ali, Mohd M.; Khan, Mohd Y.; Srimal, Rikhab C.

In: Neurochemical Research, Vol. 33, No. 6, 01.06.2008, p. 1036-1043.

Research output: Contribution to journalArticle

Shukla, PK, Khanna, VK, Ali, MM, Khan, MY & Srimal, RC 2008, 'Anti-ischemic effect of curcumin in rat brain', Neurochemical Research, vol. 33, no. 6, pp. 1036-1043. https://doi.org/10.1007/s11064-007-9547-y
Shukla, Pradeep Kumar ; Khanna, Vinay K. ; Ali, Mohd M. ; Khan, Mohd Y. ; Srimal, Rikhab C. / Anti-ischemic effect of curcumin in rat brain. In: Neurochemical Research. 2008 ; Vol. 33, No. 6. pp. 1036-1043.
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