Antidiarrhoeal and antioxidant properties of Curcuma alismatifolia leaves

Raushanara Akter, S M Raquibul Hasan, M. Mokarram Hossain, Mariam Jamila, S. Sultana Chowdhury, M. E.H. Mazumder, Shafiqur Rahman

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Hydromethanol extract of Curcuma alimatifolia leaves was scientifically evaluated for its antidiarrhoeal and antioxidant properties. Antidiarrhoeal property was studied using castor oil and MgSO 4 -induced diarrhoeal models and charcoal induced gastrointestinal motility test in Swiss Albino mice. At the doses of 250 and 500 mg/kg body weight, the extract displayed remarkable antidiarrhoeal activity, evidenced by a reduction in the rate of defecation as well as by retardation of intestinal transit of charcoal meal in test animals throughout the study period. In all of these experimental models the extract, at higher dose (500 mg/kg body weight), exhibited significant (p <0.05) antidiarrhoeal property compared to the control. Again, antioxidant potential of the extract was assessed using 1, 1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging, nitric oxide (NO) radical scavenging, total phenol and total flavonoid content determination assays. The extract displayed a dose dependent scavenging of DPPH radical and NO. Moreover, the extract was found to possess high amount of phenols and flavonoids, expressed as gallic acid and quercetin equivalents respectively. The results of the present study might indicate the usefulness of C. alismatifolia leaves in diarrhoeal disease and other disorders linked to free radical-mediated oxidative stress.

Original languageEnglish (US)
Pages (from-to)450-456
Number of pages7
JournalAustralian Journal of Basic and Applied Sciences
Volume4
Issue number3
StatePublished - Mar 1 2010

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antidiarrheal effect
antioxidants
extracts
leaves
charcoal
nitric oxide
flavonoids
dosage
Curcuma
castor oil
gastrointestinal motility
animal tests
test meals
body weight
defecation
gallic acid
albino
phenols
quercetin
biphenyl

All Science Journal Classification (ASJC) codes

  • General

Cite this

Akter, R., Hasan, S. M. R., Hossain, M. M., Jamila, M., Chowdhury, S. S., Mazumder, M. E. H., & Rahman, S. (2010). Antidiarrhoeal and antioxidant properties of Curcuma alismatifolia leaves. Australian Journal of Basic and Applied Sciences, 4(3), 450-456.

Antidiarrhoeal and antioxidant properties of Curcuma alismatifolia leaves. / Akter, Raushanara; Hasan, S M Raquibul; Hossain, M. Mokarram; Jamila, Mariam; Chowdhury, S. Sultana; Mazumder, M. E.H.; Rahman, Shafiqur.

In: Australian Journal of Basic and Applied Sciences, Vol. 4, No. 3, 01.03.2010, p. 450-456.

Research output: Contribution to journalArticle

Akter, R, Hasan, SMR, Hossain, MM, Jamila, M, Chowdhury, SS, Mazumder, MEH & Rahman, S 2010, 'Antidiarrhoeal and antioxidant properties of Curcuma alismatifolia leaves', Australian Journal of Basic and Applied Sciences, vol. 4, no. 3, pp. 450-456.
Akter R, Hasan SMR, Hossain MM, Jamila M, Chowdhury SS, Mazumder MEH et al. Antidiarrhoeal and antioxidant properties of Curcuma alismatifolia leaves. Australian Journal of Basic and Applied Sciences. 2010 Mar 1;4(3):450-456.
Akter, Raushanara ; Hasan, S M Raquibul ; Hossain, M. Mokarram ; Jamila, Mariam ; Chowdhury, S. Sultana ; Mazumder, M. E.H. ; Rahman, Shafiqur. / Antidiarrhoeal and antioxidant properties of Curcuma alismatifolia leaves. In: Australian Journal of Basic and Applied Sciences. 2010 ; Vol. 4, No. 3. pp. 450-456.
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