Antimitochondrial antibody (113-1) in the differential diagnosis of granular renal cell tumors

Satish K. Tickoo, Mahul Amin, Michael D. Linden, Min W. Lee, Richard J. Zarbo

Research output: Contribution to journalArticle

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Abstract

Abundant granular eosinophilic cytoplasm is a common feature of renal oncocytoma, chromophobe renal cell carcinoma, eosinophilic variant of papillary renal cell carcinoma, and the granular variant of clear cell renal cell carcinoma (RCC). Each of these entities has a unique architectural pattern and a distinctive molecular or cytogenetic profile. The chief reason for their distinction from one another is the difference in their biologic behavior. Careful and thorough light microscopic examination distinguishes most cases based on individual characteristic architectural and cytomorphologic features. However, precise characterization may be difficult in some cases because of overlapping morphologic features. We evaluated the antimitochondrial antibody 113-1 in an attempt to ascertain differences in immunostainlng patterns in 57 cases of granular renal tumors, including 20 renal oncocytomas, 15 chromophobe RCCs, 13 granular variants of clear cell RCC, and nine eosinophilic variants of papillary RCC. Distinctive, and nearly exclusive, staining patterns were observed among the groups, with chromophobe RCC showing peripheral accentuation of coarse cytoplasmic granules (15 of 15), renal oncocytoma with diffuse and fine granularity (20 of 20), and granular variant of clear cell RCC with irregular cytoplasmic distribution of coarse granules (11 of 13). Staining was most intense in the eosinophilic variant of papillary RCC and was generally coarsely granular and diffuse. Staining patterns also differed in clear cell areas within chromophobe RCC and the granular variant of clear cell RCC. Although clear cells in the former group showed granular staining with peripheral accentuation, most of the clear cells in the latter lacked any staining. We conclude that, in addition to distinct cytoarchitectural features, immunostaining patterns with antimitochondrial antibody 113-1 appear to be a useful discriminatory adjunct in the complex differential diagnosis of granular renal cell tumors.

Original languageEnglish (US)
Pages (from-to)922-930
Number of pages9
JournalAmerican Journal of Surgical Pathology
Volume21
Issue number8
DOIs
StatePublished - Oct 3 1997
Externally publishedYes

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Granular Cell Tumor
Renal Cell Carcinoma
Differential Diagnosis
Kidney
Antibodies
Staining and Labeling
Cytoplasmic Granules
Cytogenetics
Cytoplasm

All Science Journal Classification (ASJC) codes

  • Anatomy
  • Surgery
  • Pathology and Forensic Medicine

Cite this

Antimitochondrial antibody (113-1) in the differential diagnosis of granular renal cell tumors. / Tickoo, Satish K.; Amin, Mahul; Linden, Michael D.; Lee, Min W.; Zarbo, Richard J.

In: American Journal of Surgical Pathology, Vol. 21, No. 8, 03.10.1997, p. 922-930.

Research output: Contribution to journalArticle

Tickoo, Satish K. ; Amin, Mahul ; Linden, Michael D. ; Lee, Min W. ; Zarbo, Richard J. / Antimitochondrial antibody (113-1) in the differential diagnosis of granular renal cell tumors. In: American Journal of Surgical Pathology. 1997 ; Vol. 21, No. 8. pp. 922-930.
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