Antioxidant, antidiarrhoeal and cytotoxic properties of Punica granatum Linn.

Raquibul Hasan, Mokarram Hossain, Raushanara Akter, Mariam Jamila, Mohammed Ehsanul H Mazumder, Imamul Islam, Abdullah Faruque, Abdul Ghani, Shafiqur Rahman

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

The present study was designed to investigate antioxidant, antidiarrhoeal and cytotoxic potential of hydromethanolic extract of the fruit rind of Punica granatum Linn. A dose dependent scavenging of DPPH radical and NO was observed with significant total antioxidant capacity with the plant extract in 1, 1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging, total antioxidant capacity and nitric oxide (NO) scavenging assays. The extract was also studied for antidiarrhoeal property using castor oil and Mg-SO4-induced diarrhoeal model, and charcoal induced gastrointestinal motility test in mice. At the doses of 200 and 400 mg/kg body weight, the extract reduced the frequency and severity of diarrhoea in test animals throughout the study period. At the same doses, the extracts significantly (p < 0.001) delayed the intestinal transit of charcoal meal in test animals as compared to the control. The extract also displayed strong cytotoxic potential with LC50 value of 10 μg/ml in brine shrimp lethality bioassay.

Original languageEnglish (US)
Pages (from-to)783-788
Number of pages6
JournalLatin American Journal of Pharmacy
Volume28
Issue number5
StatePublished - 2009
Externally publishedYes

Fingerprint

Punicaceae
Antidiarrheals
Antioxidants
Charcoal
Nitric Oxide
Castor Oil
Artemia
Gastrointestinal Motility
Plant Extracts
Biological Assay
Meals
Diarrhea
Fruit
Body Weight

All Science Journal Classification (ASJC) codes

  • Pharmaceutical Science
  • Drug Discovery

Cite this

Hasan, R., Hossain, M., Akter, R., Jamila, M., Mazumder, M. E. H., Islam, I., ... Rahman, S. (2009). Antioxidant, antidiarrhoeal and cytotoxic properties of Punica granatum Linn. Latin American Journal of Pharmacy, 28(5), 783-788.

Antioxidant, antidiarrhoeal and cytotoxic properties of Punica granatum Linn. / Hasan, Raquibul; Hossain, Mokarram; Akter, Raushanara; Jamila, Mariam; Mazumder, Mohammed Ehsanul H; Islam, Imamul; Faruque, Abdullah; Ghani, Abdul; Rahman, Shafiqur.

In: Latin American Journal of Pharmacy, Vol. 28, No. 5, 2009, p. 783-788.

Research output: Contribution to journalArticle

Hasan, R, Hossain, M, Akter, R, Jamila, M, Mazumder, MEH, Islam, I, Faruque, A, Ghani, A & Rahman, S 2009, 'Antioxidant, antidiarrhoeal and cytotoxic properties of Punica granatum Linn.', Latin American Journal of Pharmacy, vol. 28, no. 5, pp. 783-788.
Hasan R, Hossain M, Akter R, Jamila M, Mazumder MEH, Islam I et al. Antioxidant, antidiarrhoeal and cytotoxic properties of Punica granatum Linn. Latin American Journal of Pharmacy. 2009;28(5):783-788.
Hasan, Raquibul ; Hossain, Mokarram ; Akter, Raushanara ; Jamila, Mariam ; Mazumder, Mohammed Ehsanul H ; Islam, Imamul ; Faruque, Abdullah ; Ghani, Abdul ; Rahman, Shafiqur. / Antioxidant, antidiarrhoeal and cytotoxic properties of Punica granatum Linn. In: Latin American Journal of Pharmacy. 2009 ; Vol. 28, No. 5. pp. 783-788.
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