Antioxidants and cancers of the esophagus and gastric cardia

Paul Terry, Jesper Lagergren, Weimin Ye, Olof Nyrén, Alicja Wolk

Research output: Contribution to journalArticle

147 Citations (Scopus)

Abstract

Antioxidant vitamins have attracted considerable attention in previous studies of esophageal squamous-cell carcinoma, but dietary studies of adenocarcinoma of the esophagus and gastric cardia remain sparse. Treating these tumors as distinct diseases, we studied intakes of vitamin C, betacarotene and alpha-tocopherol in a nationwide population-based case-control study in Sweden, with 185, 165, and 258 cases of esophageal adenocarcinoma, esophageal squamous-cell carcinoma, and gastric cardia adenocarcinoma, respectively, and 815 controls. Subiects with a high parallel intake of vitamin C, beta-carotene, and alpha-tocopherol showed a 40-50% decreased risk of both histological types of esophageal cancer compared with subjects with a low parallel in-take. Antioxidant intake was not associated with the risk of gastric cardia adenocarcinoma. Separately, vitamin C and beta-carotene reduced the risk of esophageal cancers more than alpha-tocopherol. We found that antioxidant intake is associated with similar risk reductions for both main histological types of esophageal cancer. Our findings indicate that antioxidants do not explain the diverging incidence rates of the 2 histological types of esophageal cancer. Moreover, our data suggest that inverse associations with esophageal squamous-cell carcinoma and adenocarcinoma may be stronger among subjects under presumed higher oxidative stress due to smoking or gastroesophageal reflux, respectively. Our results may be relevant for the implementation of focused, cost-effective preventive measures. (C) 2000 Wiley-Liss, Inc.

Original languageEnglish (US)
Pages (from-to)750-754
Number of pages5
JournalInternational Journal of Cancer
Volume87
Issue number5
DOIs
StatePublished - Aug 24 2000

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Cardia
Esophageal Neoplasms
Stomach Neoplasms
beta Carotene
alpha-Tocopherol
Adenocarcinoma
Antioxidants
Ascorbic Acid
Stomach
Risk Reduction Behavior
Gastroesophageal Reflux
Sweden
Vitamins
Case-Control Studies
Oxidative Stress
Smoking
Costs and Cost Analysis
Incidence
Population
Esophageal Squamous Cell Carcinoma

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

Cite this

Antioxidants and cancers of the esophagus and gastric cardia. / Terry, Paul; Lagergren, Jesper; Ye, Weimin; Nyrén, Olof; Wolk, Alicja.

In: International Journal of Cancer, Vol. 87, No. 5, 24.08.2000, p. 750-754.

Research output: Contribution to journalArticle

Terry, Paul ; Lagergren, Jesper ; Ye, Weimin ; Nyrén, Olof ; Wolk, Alicja. / Antioxidants and cancers of the esophagus and gastric cardia. In: International Journal of Cancer. 2000 ; Vol. 87, No. 5. pp. 750-754.
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