Antioxidants and cognitive training interact to affect oxidative stress and memory in APP/PSEN1 mice

F. E. Harrison, J. Allard, R. Bixler, C. Usoh, L. Li, J. M. May, Michael Mcdonald

Research output: Contribution to journalArticle

48 Citations (Scopus)

Abstract

The present study investigated the relationships among oxidative stress, β-amyloid and cognitive abilities in the APP/PSEN1 double-transgenic mouse model of Alzheimer's disease. In two experiments, long-term dietary supplements were given to aged APP/PSEN1 mice containing vitamin C alone (1 g/kg diet; Experiment 1) or in combination with a high (750 IU/kg diet, Experiments 1 and 2) or lower (400 IU/kg diet, Experiment 2) dose of vitamin E. Oxidative stress, measured by F4-neuroprostanes or malondialdehyde, was elevated in cortex of control-fed APP/PSEN1 mice and reduced to wild-type levels by vitamin supplementation. High-dose vitamin E with C was less effective at reducing oxidative stress than vitamin C alone or the low vitamin E+C diet combination. The high-dose combination also impaired water maze performance in mice of both genotypes. In Experiment 2, the lower vitamin E+C treatment attenuated spatial memory deficits in APP/PSEN1 mice and improved performance in wild-type mice in the water maze. Amyloid deposition was not reduced by antioxidant supplementation in either experiment.

Original languageEnglish (US)
Pages (from-to)203-218
Number of pages16
JournalNutritional Neuroscience
Volume12
Issue number5
DOIs
StatePublished - Oct 1 2009

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Oxidative Stress
Vitamin E
Antioxidants
Ascorbic Acid
Diet
Amyloid
Neuroprostanes
Aptitude
Water
Memory Disorders
Dietary Supplements
Malondialdehyde
Vitamins
Transgenic Mice
Alzheimer Disease
Genotype

All Science Journal Classification (ASJC) codes

  • Medicine (miscellaneous)
  • Neuroscience(all)
  • Nutrition and Dietetics

Cite this

Antioxidants and cognitive training interact to affect oxidative stress and memory in APP/PSEN1 mice. / Harrison, F. E.; Allard, J.; Bixler, R.; Usoh, C.; Li, L.; May, J. M.; Mcdonald, Michael.

In: Nutritional Neuroscience, Vol. 12, No. 5, 01.10.2009, p. 203-218.

Research output: Contribution to journalArticle

Harrison, F. E. ; Allard, J. ; Bixler, R. ; Usoh, C. ; Li, L. ; May, J. M. ; Mcdonald, Michael. / Antioxidants and cognitive training interact to affect oxidative stress and memory in APP/PSEN1 mice. In: Nutritional Neuroscience. 2009 ; Vol. 12, No. 5. pp. 203-218.
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