Antisecretory effect and oral pharmacokinetics following low dose omeprazole in man.

Colin Howden, JA Forrest, PA Meredith, JL Reid

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

The effects of single and repeated doses of omeprazole 10 mg on gastric secretion were studied in a group of six healthy subjects. Single doses had no significant effect on basal or stimulated acid output. After 7 days of treatment, there was a 93.1% reduction in basal acid output (P less than 0.02) and a 66.5% reduction in stimulated output (P less than 0.01). Pepsin output was not affected. Systemic availability of omeprazole, as reflected in the AUC, increased significantly (P less than 0.05) with repeated dosing. Low doses of omeprazole can produce substantial reductions in acid output after repeated dosing. 1985 The British Pharmacological Society

Original languageEnglish (US)
Pages (from-to)137-139
Number of pages3
JournalBritish Journal of Clinical Pharmacology
Volume20
Issue number2
DOIs
StatePublished - Jan 1 1985
Externally publishedYes

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Omeprazole
Pharmacokinetics
Acids
Pepsin A
Area Under Curve
Stomach
Healthy Volunteers
Therapeutics

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Pharmacology (medical)

Cite this

Antisecretory effect and oral pharmacokinetics following low dose omeprazole in man. / Howden, Colin; Forrest, JA; Meredith, PA; Reid, JL.

In: British Journal of Clinical Pharmacology, Vol. 20, No. 2, 01.01.1985, p. 137-139.

Research output: Contribution to journalArticle

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