Antisecretory effect and oral pharmacokinetics of omeprazole in patients with chronic renal failure

Colin Howden, C. D. Payton, P. A. Meredith, D. M.A. Hughes, A. I. Macdougall, J. L. Reid, J. A.H. Forrest

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

The inhibitory effect of omeprazole on gastric acid secretion was tested in a group of patients on haemodialysis for chronic renal failure. Single 30 mg doses almost totally inhibited basal acid output on both dialysis and non-dialysis days. Plateau acid output was reduced by a mean of 77% and 90% on non-dialysis and dialysis days respectively. The absorption and pharmacokinetic profile of omeprazole were not affected by dialysis. Omeprazole was not recoverable from dialysis fluid. It is concluded that omeprazole is a potent inhibitor of gastric acid secretion in patients with chronic renal failure, and its effect is not influenced by haemodialysis.

Original languageEnglish (US)
Pages (from-to)637-640
Number of pages4
JournalEuropean Journal of Clinical Pharmacology
Volume28
Issue number6
DOIs
StatePublished - Nov 1 1985
Externally publishedYes

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Omeprazole
Chronic Kidney Failure
Dialysis
Pharmacokinetics
Gastric Acid
Renal Dialysis
Acids

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Pharmacology (medical)

Cite this

Howden, C., Payton, C. D., Meredith, P. A., Hughes, D. M. A., Macdougall, A. I., Reid, J. L., & Forrest, J. A. H. (1985). Antisecretory effect and oral pharmacokinetics of omeprazole in patients with chronic renal failure. European Journal of Clinical Pharmacology, 28(6), 637-640. https://doi.org/10.1007/BF00607907

Antisecretory effect and oral pharmacokinetics of omeprazole in patients with chronic renal failure. / Howden, Colin; Payton, C. D.; Meredith, P. A.; Hughes, D. M.A.; Macdougall, A. I.; Reid, J. L.; Forrest, J. A.H.

In: European Journal of Clinical Pharmacology, Vol. 28, No. 6, 01.11.1985, p. 637-640.

Research output: Contribution to journalArticle

Howden, C, Payton, CD, Meredith, PA, Hughes, DMA, Macdougall, AI, Reid, JL & Forrest, JAH 1985, 'Antisecretory effect and oral pharmacokinetics of omeprazole in patients with chronic renal failure', European Journal of Clinical Pharmacology, vol. 28, no. 6, pp. 637-640. https://doi.org/10.1007/BF00607907
Howden, Colin ; Payton, C. D. ; Meredith, P. A. ; Hughes, D. M.A. ; Macdougall, A. I. ; Reid, J. L. ; Forrest, J. A.H. / Antisecretory effect and oral pharmacokinetics of omeprazole in patients with chronic renal failure. In: European Journal of Clinical Pharmacology. 1985 ; Vol. 28, No. 6. pp. 637-640.
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