Anxiogenic activity of methanol extracts of Artocarpus lacucha buch.-ham. fruit parts and leaf in mice

Mokarram Hossain, S M Raquibul Hasan, Monjuara Mukta, Raushanara Akter, Md Ehsanul Hoque Mazumder, Abdullah Faruque, Md Sohel Rana

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

In this study, hydromethanol extracts of fruit pulp, pericarp, seed and leaf (coded as ALP, ALPC, ALS and ALL respectively) of Artocarpus lacucha at 200 and 400 mg/kg b.w., p.o., were evaluated for possible anxiogenic activity using standard animal behavioural models, such as hole cross, open field, elevated plus-maze (EPM) and dark/light box tests. All the extracts exhibited a dose dependent and significant (p < 0.05-0.001) decrease of motor activity and exploratory behaviour in hole cross and open field tests. The extracts also significantly increased both the number of visits to and time spent in the corners of the open field. In EPM, the extracts displayed dose dependent and significant (p < 0.05-0.001) decrease in total number of entries and time spent in the open arms and increase in total number of entries in the closed arm. In addition, all the extracts significantly (p < 0.05-0.001) reversed the anxiolytic effect of diazepam in EPM. The extracts also displayed anxiogenic effect in light/dark box as evident by significant (p < 0.001) reduction of time spent in the lit box and significant (p < 0.05-0.001) increment of time spent in the dark box. The pulp extract displayed maximum effect in all the tested behavioural models. Reversal of anxiolytic activity of diazepam suggests the involvement of GABA systems in the anxiogenic activity exhibited by the crude extracts.

Original languageEnglish (US)
Pages (from-to)592-603
Number of pages12
JournalEuropean Journal of Scientific Research
Volume46
Issue number4
StatePublished - Jan 1 2010

Fingerprint

Artocarpus lacucha
Artocarpus
Anti-Anxiety Agents
Fruit
ham
Diazepam
Fruits
Pulp
Methanol
methanol
Mouse
Leaves
fruit
fruits
mice
extracts
Complex Mixtures
gamma-Aminobutyric Acid
Seed
leaves

All Science Journal Classification (ASJC) codes

  • Computer Science(all)
  • Mathematics(all)
  • Materials Science(all)
  • Agricultural and Biological Sciences(all)
  • Engineering(all)
  • Earth and Planetary Sciences(all)

Cite this

Hossain, M., Hasan, S. M. R., Mukta, M., Akter, R., Mazumder, M. E. H., Faruque, A., & Rana, M. S. (2010). Anxiogenic activity of methanol extracts of Artocarpus lacucha buch.-ham. fruit parts and leaf in mice. European Journal of Scientific Research, 46(4), 592-603.

Anxiogenic activity of methanol extracts of Artocarpus lacucha buch.-ham. fruit parts and leaf in mice. / Hossain, Mokarram; Hasan, S M Raquibul; Mukta, Monjuara; Akter, Raushanara; Mazumder, Md Ehsanul Hoque; Faruque, Abdullah; Rana, Md Sohel.

In: European Journal of Scientific Research, Vol. 46, No. 4, 01.01.2010, p. 592-603.

Research output: Contribution to journalArticle

Hossain, M, Hasan, SMR, Mukta, M, Akter, R, Mazumder, MEH, Faruque, A & Rana, MS 2010, 'Anxiogenic activity of methanol extracts of Artocarpus lacucha buch.-ham. fruit parts and leaf in mice', European Journal of Scientific Research, vol. 46, no. 4, pp. 592-603.
Hossain, Mokarram ; Hasan, S M Raquibul ; Mukta, Monjuara ; Akter, Raushanara ; Mazumder, Md Ehsanul Hoque ; Faruque, Abdullah ; Rana, Md Sohel. / Anxiogenic activity of methanol extracts of Artocarpus lacucha buch.-ham. fruit parts and leaf in mice. In: European Journal of Scientific Research. 2010 ; Vol. 46, No. 4. pp. 592-603.
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