Apexification: The beginning of its end

Research output: Contribution to journalReview article

75 Citations (Scopus)

Abstract

Apexification is a procedure for treating and preserving immature permanent teeth that have lost pulp vitality. It contrasts apexogenesis in terms of its outcome in that apical maturation and normal root thickness cannot be obtained. Apexification has been a routine practice for such teeth for many decades, and despite a literature replete with discussion, including recent artificial barrier methods with mineral trioxide aggregate, ultimately there has been no major breakthrough to improve this treatment. Recently, two new clinical concepts have emerged. One involves a revitalization approach to achieve tissue generation and regeneration. In this method, new living tissue is expected to form in the cleaned canal space, allowing continued root development in terms of both length and thickness. The other is the active pursuit of pulp/dentine regeneration via tissue engineering technology to implant or re-grow pulps. Although the technology is still at its infancy, it has the potential to benefit immature pulpless teeth by allowing continued growth and maturation. With this understanding, it may be predicted that apexification will become less needed in years to come. This study will overview the recent concept of pulp revitalization in the treatment of immature teeth with nonvital pulps and the emerging research on pulp tissue engineering and regeneration.

Original languageEnglish (US)
Pages (from-to)855-866
Number of pages12
JournalInternational Endodontic Journal
Volume42
Issue number10
DOIs
StatePublished - Jan 1 2009

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Apexification
Nonvital Tooth
Regeneration
Tissue Engineering
Tooth
Technology
Dentin
Growth
Research

All Science Journal Classification (ASJC) codes

  • Dentistry(all)

Cite this

Apexification : The beginning of its end. / Huang, George.

In: International Endodontic Journal, Vol. 42, No. 10, 01.01.2009, p. 855-866.

Research output: Contribution to journalReview article

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