Applicability of adult techniques for ovarian preservation to childhood cancer patients

Laura Detti, Daniel C. Martin, Lucy J. Williams

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Purpose: To appraise the feasibility of current adult medical and surgical techniques for ovarian preservation in prepubertal and adolescent girls with cancer. Methods: Literature search using PubMed and SCOPUS up to February 2012. In addition, the reference lists of selected studies and all identified systematic and narrative reviews were scanned for relevant references. Inclusion criteria were ovarian preservation and cancer. Exclusion criteria were non-English publications, letters, personal communications, and ovarian preservation for conditions other than cancer. Results: Data from the selected publications was interpreted and discussed in the relevant sections. Cryopreservation of ovarian tissue followed by autologous transplant represents the only surgical option available for pre-pubertal girls and adolescents who cannot delay the start of chemotherapy. Few studies report on pre-pubertal and adolescent girls undergoing ovarian preservation surgeries with good harvesting, and no follow-up has been conveyed, to date. Outcomes of ovarian function after ovarian suppression with GnRH-analogs in adults have been controversial and no reports are available for pre-pubertal girls. Conclusions: Autologous transplantation of cryopreserved ovarian cortex probably represents the best option for preservation of fertility and hormonal function in childhood cancer females; however, future research needs to address the safety of this technique, especially in patients with blood-borne cancers. Ovarian suppression with GnRHanalogs at the time of chemotherapy treatment has not proven to be superior to non-suppression for fertility preservation purposes in adults. Not enough evidence is presently available in childhood cancer patients.

Original languageEnglish (US)
Pages (from-to)985-995
Number of pages11
JournalJournal of Assisted Reproduction and Genetics
Volume29
Issue number9
DOIs
StatePublished - Sep 1 2012

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Fertility Preservation
Neoplasms
Publications
Drug Therapy
Autologous Transplantation
Cryopreservation
Autografts
PubMed
Gonadotropin-Releasing Hormone
Ovarian Neoplasms
Communication
Safety
Therapeutics

All Science Journal Classification (ASJC) codes

  • Reproductive Medicine
  • Genetics
  • Obstetrics and Gynecology
  • Developmental Biology
  • Genetics(clinical)

Cite this

Applicability of adult techniques for ovarian preservation to childhood cancer patients. / Detti, Laura; Martin, Daniel C.; Williams, Lucy J.

In: Journal of Assisted Reproduction and Genetics, Vol. 29, No. 9, 01.09.2012, p. 985-995.

Research output: Contribution to journalArticle

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