Application of genomic resources and gene expression profiles to identify genes that regulate bone destiny

Weikuan Gu, X. M. Li, B. A. Roe, K. H.William Lau, S. Mohan, D. J. Baylink

Research output: Contribution to journalReview article

7 Citations (Scopus)

Abstract

Inadequate bone density is the strongest determinant of subsequent osteoporotic fracture. More than 70% of the variability in human bone density has been attributed to genetic factors. Therefore, the identification of genes regulating peak bone density represents a major advance in both the understanding of pathways that regulate bone density and the pathogenesis of diseases such as osteoporosis. Although association studies have revealed many candidate genes, the exact roles of these genes in the regulation of bone density are not clearly defined. Recently, a large number of bone density quantitative trait loci (QTLs) have been identified using mouse models and human populations. However, none of the genes responsible for these QTLs have been identified. Thus, the regulation of bone density is likely far more complicated than previously anticipated. Over the next decade, DNA microarrays, combined with sophisticated informatics and genomic databases, will provide a new generation of molecular tools for the identification and functional studies of genes responsible for bone density. This review intends to provide an update on the application of genomic resources and gene expression profiles to identify genes that regulate bone density. First, the progress and problems with association studies for QTL identification of bone density will be summarized. Then current resources of genomic sequences and ESTs that can be used for the identification of QTL genes will be discussed. Finally information on the 207 ESTs that are expressed in the bone and 39 ESTs that we have identified within the QTL regions will be presented. It is anticipated that this review will stimulate further studies on candidate genes that regulate bone density by taking advantage of the rapidly emerging genomic data.

Original languageEnglish (US)
Pages (from-to)75-102
Number of pages28
JournalCurrent Genomics
Volume4
Issue number1
DOIs
StatePublished - Jan 1 2003

Fingerprint

Transcriptome
Bone Density
Bone and Bones
Quantitative Trait Loci
Genes
Expressed Sequence Tags
Informatics
Osteoporotic Fractures
Oligonucleotide Array Sequence Analysis
Osteoporosis
Databases

All Science Journal Classification (ASJC) codes

  • Genetics
  • Genetics(clinical)

Cite this

Application of genomic resources and gene expression profiles to identify genes that regulate bone destiny. / Gu, Weikuan; Li, X. M.; Roe, B. A.; Lau, K. H.William; Mohan, S.; Baylink, D. J.

In: Current Genomics, Vol. 4, No. 1, 01.01.2003, p. 75-102.

Research output: Contribution to journalReview article

Gu, Weikuan ; Li, X. M. ; Roe, B. A. ; Lau, K. H.William ; Mohan, S. ; Baylink, D. J. / Application of genomic resources and gene expression profiles to identify genes that regulate bone destiny. In: Current Genomics. 2003 ; Vol. 4, No. 1. pp. 75-102.
@article{5a982431c44d4ce1afc300437493c2ca,
title = "Application of genomic resources and gene expression profiles to identify genes that regulate bone destiny",
abstract = "Inadequate bone density is the strongest determinant of subsequent osteoporotic fracture. More than 70{\%} of the variability in human bone density has been attributed to genetic factors. Therefore, the identification of genes regulating peak bone density represents a major advance in both the understanding of pathways that regulate bone density and the pathogenesis of diseases such as osteoporosis. Although association studies have revealed many candidate genes, the exact roles of these genes in the regulation of bone density are not clearly defined. Recently, a large number of bone density quantitative trait loci (QTLs) have been identified using mouse models and human populations. However, none of the genes responsible for these QTLs have been identified. Thus, the regulation of bone density is likely far more complicated than previously anticipated. Over the next decade, DNA microarrays, combined with sophisticated informatics and genomic databases, will provide a new generation of molecular tools for the identification and functional studies of genes responsible for bone density. This review intends to provide an update on the application of genomic resources and gene expression profiles to identify genes that regulate bone density. First, the progress and problems with association studies for QTL identification of bone density will be summarized. Then current resources of genomic sequences and ESTs that can be used for the identification of QTL genes will be discussed. Finally information on the 207 ESTs that are expressed in the bone and 39 ESTs that we have identified within the QTL regions will be presented. It is anticipated that this review will stimulate further studies on candidate genes that regulate bone density by taking advantage of the rapidly emerging genomic data.",
author = "Weikuan Gu and Li, {X. M.} and Roe, {B. A.} and Lau, {K. H.William} and S. Mohan and Baylink, {D. J.}",
year = "2003",
month = "1",
day = "1",
doi = "10.2174/1389202033350146",
language = "English (US)",
volume = "4",
pages = "75--102",
journal = "Current Genomics",
issn = "1389-2029",
publisher = "Bentham Science Publishers B.V.",
number = "1",

}

TY - JOUR

T1 - Application of genomic resources and gene expression profiles to identify genes that regulate bone destiny

AU - Gu, Weikuan

AU - Li, X. M.

AU - Roe, B. A.

AU - Lau, K. H.William

AU - Mohan, S.

AU - Baylink, D. J.

PY - 2003/1/1

Y1 - 2003/1/1

N2 - Inadequate bone density is the strongest determinant of subsequent osteoporotic fracture. More than 70% of the variability in human bone density has been attributed to genetic factors. Therefore, the identification of genes regulating peak bone density represents a major advance in both the understanding of pathways that regulate bone density and the pathogenesis of diseases such as osteoporosis. Although association studies have revealed many candidate genes, the exact roles of these genes in the regulation of bone density are not clearly defined. Recently, a large number of bone density quantitative trait loci (QTLs) have been identified using mouse models and human populations. However, none of the genes responsible for these QTLs have been identified. Thus, the regulation of bone density is likely far more complicated than previously anticipated. Over the next decade, DNA microarrays, combined with sophisticated informatics and genomic databases, will provide a new generation of molecular tools for the identification and functional studies of genes responsible for bone density. This review intends to provide an update on the application of genomic resources and gene expression profiles to identify genes that regulate bone density. First, the progress and problems with association studies for QTL identification of bone density will be summarized. Then current resources of genomic sequences and ESTs that can be used for the identification of QTL genes will be discussed. Finally information on the 207 ESTs that are expressed in the bone and 39 ESTs that we have identified within the QTL regions will be presented. It is anticipated that this review will stimulate further studies on candidate genes that regulate bone density by taking advantage of the rapidly emerging genomic data.

AB - Inadequate bone density is the strongest determinant of subsequent osteoporotic fracture. More than 70% of the variability in human bone density has been attributed to genetic factors. Therefore, the identification of genes regulating peak bone density represents a major advance in both the understanding of pathways that regulate bone density and the pathogenesis of diseases such as osteoporosis. Although association studies have revealed many candidate genes, the exact roles of these genes in the regulation of bone density are not clearly defined. Recently, a large number of bone density quantitative trait loci (QTLs) have been identified using mouse models and human populations. However, none of the genes responsible for these QTLs have been identified. Thus, the regulation of bone density is likely far more complicated than previously anticipated. Over the next decade, DNA microarrays, combined with sophisticated informatics and genomic databases, will provide a new generation of molecular tools for the identification and functional studies of genes responsible for bone density. This review intends to provide an update on the application of genomic resources and gene expression profiles to identify genes that regulate bone density. First, the progress and problems with association studies for QTL identification of bone density will be summarized. Then current resources of genomic sequences and ESTs that can be used for the identification of QTL genes will be discussed. Finally information on the 207 ESTs that are expressed in the bone and 39 ESTs that we have identified within the QTL regions will be presented. It is anticipated that this review will stimulate further studies on candidate genes that regulate bone density by taking advantage of the rapidly emerging genomic data.

UR - http://www.scopus.com/inward/record.url?scp=0037245165&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0037245165&partnerID=8YFLogxK

U2 - 10.2174/1389202033350146

DO - 10.2174/1389202033350146

M3 - Review article

VL - 4

SP - 75

EP - 102

JO - Current Genomics

JF - Current Genomics

SN - 1389-2029

IS - 1

ER -