Aquaporin-2 water channel in developing quail kidney

Possible role in programming adult fluid homeostasis

Hiroko Nishimura, Yimu Yang, Keith Lau, Rhonda J. Kuykindoll, Zheng Fan, Ken'ichi Yamaguchi, Tadashi Yamamoto

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Avian kidneys have loopless and looped nephrons; a countercurrent multiplier mechanism operates in the latter by NaCl recycling. We identified an aquaporin-2 (AQP2) homolog in apical/subapical regions of cortical and medullary collecting duct (CD) cells in kidneys of Japanese quail (q), Coturnix japonica. We investigated whether undernutrition during the embryonic/maturation period retards kidney and AQP2 development in quail and programs impaired volume regulation in adults. Protocols included 1) time course and 2) effects of 5-10% egg white withdrawal (EwW) or 48-h post-hatch food deprivation (FD) on nephron growth and qAQP2 mRNA expression, and 3) effects of EwW and FD on qAQP2 mRNA responses to 72-h water deprivation in adults. In metanephric kidneys, qAQP2 mRNA is expressed in medullary CDs at embryonic day 10; distribution and intensity increase during maturation. The number and size of glomeruli continue to increase after birth, whereas nephrogenic zones decrease. In EwW embryos, qAQP2 mRNA expression is initially delayed, then restored; birth weight and hatching rate are lower than in controls. Adults from EwW embryos and FD chicks have fewer (P < 0.01) glomeruli. Water deprivation reduces body weight more in EwW birds than in controls. The results suggest that qAQP2 evolved in metanephric kidneys and that undernutrition may retard nephrogenesis, leading to impaired adult water homeostasis.

Original languageEnglish (US)
JournalAmerican Journal of Physiology - Regulatory Integrative and Comparative Physiology
Volume293
Issue number5
DOIs
StatePublished - Nov 1 2007

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Aquaporin 2
Egg White
Aquaporins
Quail
Homeostasis
Food Deprivation
Kidney
Water Deprivation
Coturnix
Messenger RNA
Nephrons
Malnutrition
Embryonic Structures
Recycling
Birth Weight
Birds
Body Weight
Parturition
Water
Growth

All Science Journal Classification (ASJC) codes

  • Physiology
  • Physiology (medical)

Cite this

Aquaporin-2 water channel in developing quail kidney : Possible role in programming adult fluid homeostasis. / Nishimura, Hiroko; Yang, Yimu; Lau, Keith; Kuykindoll, Rhonda J.; Fan, Zheng; Yamaguchi, Ken'ichi; Yamamoto, Tadashi.

In: American Journal of Physiology - Regulatory Integrative and Comparative Physiology, Vol. 293, No. 5, 01.11.2007.

Research output: Contribution to journalArticle

Nishimura, Hiroko ; Yang, Yimu ; Lau, Keith ; Kuykindoll, Rhonda J. ; Fan, Zheng ; Yamaguchi, Ken'ichi ; Yamamoto, Tadashi. / Aquaporin-2 water channel in developing quail kidney : Possible role in programming adult fluid homeostasis. In: American Journal of Physiology - Regulatory Integrative and Comparative Physiology. 2007 ; Vol. 293, No. 5.
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