Arachidonic acid status correlates with first year growth in preterm infants

Susan E. Carlson, Susan H. Werkman, Jeanette M. Peeples, Richard J. Cooke, Elizabeth Tolley

Research output: Contribution to journalArticle

394 Citations (Scopus)

Abstract

Diets deficient in the ω-6 fatty acid linoleic acid reduce arachidonic acid (Ach) concentrations and retard growth of developing animals and humans. Nevertheless, plasma phosphatidylcholine Ach concentrations declined from 84 ± 23 mg/liter at birth to a nadir of 38 ± 11 mg/liter at 4 mo of age in preterm infants fed commercial formulas with linoleic acid, and weight normalized to that of term infants fell progressively beginning at 2 mo of age. The nadir of plasma phosphatidylcholine Ach (31 ± 7 mg/liter) and growth were further reduced by formula containing marine oil compared with the commercial formulas. Ach status (defined as the mean plasma phosphatidylcholine Ach concentration at 2, 4, and 6.5 mo) correlated with one or more measures of normalized growth through 12 mo. Ach status and maternal height accounted for as much as 59% of the weight variance and 68% of the length variance in infants fed standard formulas. Better Ach status was not from higher energy intakes. A conditional Ach deficiency in preterm infants may contribute to growth over the first year of life. On the strength of the relationship between Ach status and growth, we hypothesize that dietary Ach could improve first year growth of preterm infants.

Original languageEnglish (US)
Pages (from-to)1073-1077
Number of pages5
JournalProceedings of the National Academy of Sciences of the United States of America
Volume90
Issue number3
DOIs
StatePublished - Feb 1 1993

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Arachidonic Acid
Premature Infants
Growth
Phosphatidylcholines
Linoleic Acid
Weights and Measures
Energy Intake
Oils
Fatty Acids
Mothers
Parturition
Diet

All Science Journal Classification (ASJC) codes

  • General

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Arachidonic acid status correlates with first year growth in preterm infants. / Carlson, Susan E.; Werkman, Susan H.; Peeples, Jeanette M.; Cooke, Richard J.; Tolley, Elizabeth.

In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 90, No. 3, 01.02.1993, p. 1073-1077.

Research output: Contribution to journalArticle

Carlson, Susan E. ; Werkman, Susan H. ; Peeples, Jeanette M. ; Cooke, Richard J. ; Tolley, Elizabeth. / Arachidonic acid status correlates with first year growth in preterm infants. In: Proceedings of the National Academy of Sciences of the United States of America. 1993 ; Vol. 90, No. 3. pp. 1073-1077.
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