Arenastatin A, a potent cytotoxic depsipeptide from the okinawan marine sponge Dysidea arenaria

Motomasa Kobayashi, Shunji Aoki, Naoki Ohyabu, Michio Kurosu, Weiqi Wang, Isao Kitagawa

Research output: Contribution to journalArticle

111 Citations (Scopus)

Abstract

Arenastatin A (1) has been isolated from the Okinawan marine sponge Dysidea arenaria and the chemical structure including parts of the absolute configurations elucidated. Arenastatin A (1) is a cyclic didepsipeptide and exhibited extremely potent cytotoxicity against KB cells at IC50 5 pg/ml.

Original languageEnglish (US)
Pages (from-to)7969-7972
Number of pages4
JournalTetrahedron Letters
Volume35
Issue number43
DOIs
StatePublished - Oct 24 1994

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Dysidea
Depsipeptides
Porifera
KB Cells
Cytotoxicity
Inhibitory Concentration 50
arenastatin A

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

Cite this

Arenastatin A, a potent cytotoxic depsipeptide from the okinawan marine sponge Dysidea arenaria. / Kobayashi, Motomasa; Aoki, Shunji; Ohyabu, Naoki; Kurosu, Michio; Wang, Weiqi; Kitagawa, Isao.

In: Tetrahedron Letters, Vol. 35, No. 43, 24.10.1994, p. 7969-7972.

Research output: Contribution to journalArticle

Kobayashi, Motomasa ; Aoki, Shunji ; Ohyabu, Naoki ; Kurosu, Michio ; Wang, Weiqi ; Kitagawa, Isao. / Arenastatin A, a potent cytotoxic depsipeptide from the okinawan marine sponge Dysidea arenaria. In: Tetrahedron Letters. 1994 ; Vol. 35, No. 43. pp. 7969-7972.
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