Arterial stiffness and gait speed in older adults with and without peripheral arterial disease

Nora L. Watson, Kim Sutton-Tyrrell, Ada O. Youk, Robert M. Boudreau, Rachel H. MacKey, Eleanor M. Simonsick, Caterina Rosano, Susan E. Hardy, B. Gwen Windham, Tamara B. Harris, Samer S. Najjar, Edward G. Lakatta, Hal H. Atkinson, Karen Johnson, Douglas C. Bauer, Anne B. Nemwan

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

Background Central arterial stiffness is increasingly recognized as an important predictor of cardiovascular events and mortality in older adults; however, few studies have evaluated the association of arterial stiffness with mobility decline, a common consequence of vascular disease. Methods We analyzed the association of pulse wave velocity (PWV), a measure of aortic stiffness, with longitudinal gait speed over 7 years in 2,172 participants in the Health, Aging and Body Composition (ABC) Study (mean age s.d. 73.6±2.9 years, 48% men, 39% black). Results In mixed-effects models adjusted for demographics, each s.d. (396cm/s) higher PWV was associated with<0.015 (s.e.<0.004) m/s slower gait at baseline and throughout the study period in the full cohort (P<0.001); this relationship was largely explained by hypertension and other vascular risk factors. Among participants with peripheral arterial disease (PAD) (n = 261; 12.7%), each s.d. higher PWV was independently associated with<0.028 (s.e.<0.010) m/s slower gait speed at baseline and throughout the study period (P<0.01). Conclusions These findings suggest that aortic stiffness may be especially detrimental to mobility in older adults with already compromised arterial function.

Original languageEnglish (US)
Pages (from-to)90-95
Number of pages6
JournalAmerican journal of hypertension
Volume24
Issue number1
DOIs
StatePublished - Jan 1 2011

Fingerprint

Vascular Stiffness
Peripheral Arterial Disease
Pulse Wave Analysis
Body Composition
Gait
Vascular Diseases
Demography
Hypertension
Mortality
Walking Speed
Health

All Science Journal Classification (ASJC) codes

  • Internal Medicine

Cite this

Watson, N. L., Sutton-Tyrrell, K., Youk, A. O., Boudreau, R. M., MacKey, R. H., Simonsick, E. M., ... Nemwan, A. B. (2011). Arterial stiffness and gait speed in older adults with and without peripheral arterial disease. American journal of hypertension, 24(1), 90-95. https://doi.org/10.1038/ajh.2010.193

Arterial stiffness and gait speed in older adults with and without peripheral arterial disease. / Watson, Nora L.; Sutton-Tyrrell, Kim; Youk, Ada O.; Boudreau, Robert M.; MacKey, Rachel H.; Simonsick, Eleanor M.; Rosano, Caterina; Hardy, Susan E.; Windham, B. Gwen; Harris, Tamara B.; Najjar, Samer S.; Lakatta, Edward G.; Atkinson, Hal H.; Johnson, Karen; Bauer, Douglas C.; Nemwan, Anne B.

In: American journal of hypertension, Vol. 24, No. 1, 01.01.2011, p. 90-95.

Research output: Contribution to journalArticle

Watson, NL, Sutton-Tyrrell, K, Youk, AO, Boudreau, RM, MacKey, RH, Simonsick, EM, Rosano, C, Hardy, SE, Windham, BG, Harris, TB, Najjar, SS, Lakatta, EG, Atkinson, HH, Johnson, K, Bauer, DC & Nemwan, AB 2011, 'Arterial stiffness and gait speed in older adults with and without peripheral arterial disease', American journal of hypertension, vol. 24, no. 1, pp. 90-95. https://doi.org/10.1038/ajh.2010.193
Watson NL, Sutton-Tyrrell K, Youk AO, Boudreau RM, MacKey RH, Simonsick EM et al. Arterial stiffness and gait speed in older adults with and without peripheral arterial disease. American journal of hypertension. 2011 Jan 1;24(1):90-95. https://doi.org/10.1038/ajh.2010.193
Watson, Nora L. ; Sutton-Tyrrell, Kim ; Youk, Ada O. ; Boudreau, Robert M. ; MacKey, Rachel H. ; Simonsick, Eleanor M. ; Rosano, Caterina ; Hardy, Susan E. ; Windham, B. Gwen ; Harris, Tamara B. ; Najjar, Samer S. ; Lakatta, Edward G. ; Atkinson, Hal H. ; Johnson, Karen ; Bauer, Douglas C. ; Nemwan, Anne B. / Arterial stiffness and gait speed in older adults with and without peripheral arterial disease. In: American journal of hypertension. 2011 ; Vol. 24, No. 1. pp. 90-95.
@article{7e0dccdc04c241d583753cb3deffdb66,
title = "Arterial stiffness and gait speed in older adults with and without peripheral arterial disease",
abstract = "Background Central arterial stiffness is increasingly recognized as an important predictor of cardiovascular events and mortality in older adults; however, few studies have evaluated the association of arterial stiffness with mobility decline, a common consequence of vascular disease. Methods We analyzed the association of pulse wave velocity (PWV), a measure of aortic stiffness, with longitudinal gait speed over 7 years in 2,172 participants in the Health, Aging and Body Composition (ABC) Study (mean age s.d. 73.6±2.9 years, 48{\%} men, 39{\%} black). Results In mixed-effects models adjusted for demographics, each s.d. (396cm/s) higher PWV was associated with<0.015 (s.e.<0.004) m/s slower gait at baseline and throughout the study period in the full cohort (P<0.001); this relationship was largely explained by hypertension and other vascular risk factors. Among participants with peripheral arterial disease (PAD) (n = 261; 12.7{\%}), each s.d. higher PWV was independently associated with<0.028 (s.e.<0.010) m/s slower gait speed at baseline and throughout the study period (P<0.01). Conclusions These findings suggest that aortic stiffness may be especially detrimental to mobility in older adults with already compromised arterial function.",
author = "Watson, {Nora L.} and Kim Sutton-Tyrrell and Youk, {Ada O.} and Boudreau, {Robert M.} and MacKey, {Rachel H.} and Simonsick, {Eleanor M.} and Caterina Rosano and Hardy, {Susan E.} and Windham, {B. Gwen} and Harris, {Tamara B.} and Najjar, {Samer S.} and Lakatta, {Edward G.} and Atkinson, {Hal H.} and Karen Johnson and Bauer, {Douglas C.} and Nemwan, {Anne B.}",
year = "2011",
month = "1",
day = "1",
doi = "10.1038/ajh.2010.193",
language = "English (US)",
volume = "24",
pages = "90--95",
journal = "American Journal of Hypertension",
issn = "0895-7061",
publisher = "Oxford University Press",
number = "1",

}

TY - JOUR

T1 - Arterial stiffness and gait speed in older adults with and without peripheral arterial disease

AU - Watson, Nora L.

AU - Sutton-Tyrrell, Kim

AU - Youk, Ada O.

AU - Boudreau, Robert M.

AU - MacKey, Rachel H.

AU - Simonsick, Eleanor M.

AU - Rosano, Caterina

AU - Hardy, Susan E.

AU - Windham, B. Gwen

AU - Harris, Tamara B.

AU - Najjar, Samer S.

AU - Lakatta, Edward G.

AU - Atkinson, Hal H.

AU - Johnson, Karen

AU - Bauer, Douglas C.

AU - Nemwan, Anne B.

PY - 2011/1/1

Y1 - 2011/1/1

N2 - Background Central arterial stiffness is increasingly recognized as an important predictor of cardiovascular events and mortality in older adults; however, few studies have evaluated the association of arterial stiffness with mobility decline, a common consequence of vascular disease. Methods We analyzed the association of pulse wave velocity (PWV), a measure of aortic stiffness, with longitudinal gait speed over 7 years in 2,172 participants in the Health, Aging and Body Composition (ABC) Study (mean age s.d. 73.6±2.9 years, 48% men, 39% black). Results In mixed-effects models adjusted for demographics, each s.d. (396cm/s) higher PWV was associated with<0.015 (s.e.<0.004) m/s slower gait at baseline and throughout the study period in the full cohort (P<0.001); this relationship was largely explained by hypertension and other vascular risk factors. Among participants with peripheral arterial disease (PAD) (n = 261; 12.7%), each s.d. higher PWV was independently associated with<0.028 (s.e.<0.010) m/s slower gait speed at baseline and throughout the study period (P<0.01). Conclusions These findings suggest that aortic stiffness may be especially detrimental to mobility in older adults with already compromised arterial function.

AB - Background Central arterial stiffness is increasingly recognized as an important predictor of cardiovascular events and mortality in older adults; however, few studies have evaluated the association of arterial stiffness with mobility decline, a common consequence of vascular disease. Methods We analyzed the association of pulse wave velocity (PWV), a measure of aortic stiffness, with longitudinal gait speed over 7 years in 2,172 participants in the Health, Aging and Body Composition (ABC) Study (mean age s.d. 73.6±2.9 years, 48% men, 39% black). Results In mixed-effects models adjusted for demographics, each s.d. (396cm/s) higher PWV was associated with<0.015 (s.e.<0.004) m/s slower gait at baseline and throughout the study period in the full cohort (P<0.001); this relationship was largely explained by hypertension and other vascular risk factors. Among participants with peripheral arterial disease (PAD) (n = 261; 12.7%), each s.d. higher PWV was independently associated with<0.028 (s.e.<0.010) m/s slower gait speed at baseline and throughout the study period (P<0.01). Conclusions These findings suggest that aortic stiffness may be especially detrimental to mobility in older adults with already compromised arterial function.

UR - http://www.scopus.com/inward/record.url?scp=78650275484&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=78650275484&partnerID=8YFLogxK

U2 - 10.1038/ajh.2010.193

DO - 10.1038/ajh.2010.193

M3 - Article

VL - 24

SP - 90

EP - 95

JO - American Journal of Hypertension

JF - American Journal of Hypertension

SN - 0895-7061

IS - 1

ER -