Asacol®-induced neutropenia resolution without the use of granulocyte colony-stimulating factor

Brian T. Fowler, Tina Gupta, Muhammad Bilal

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

We report a case of neutropenia and gram-negative septicemia in a 73-year-old male with ulcerative colitis. During the hospital course, medications were adjusted according to rare accounts of drug-induced neutropenia. While the substitution of propafenone for another antiarrhythmic brought about no change in the patient's absolute neutrophil count, the cessation of Asacol® (Warner Chilcott, Rockaway, NJ) was followed by a significant improvement in the neutropenic state. In fact, this neutrophil count continued to trend upward for months following. We thereby conclude that Asacol® carries the potential to induce neutropenia and that this reaction may be reversed in some patients solely by discontinuing the medication and without the aid of stimulating factors such as filgrastim.

Original languageEnglish (US)
Pages (from-to)1167-1169
Number of pages3
JournalSouthern Medical Journal
Volume103
Issue number11
DOIs
StatePublished - Nov 1 2010

Fingerprint

Mesalamine
Granulocyte Colony-Stimulating Factor
Neutropenia
Neutrophils
Propafenone
Ulcerative Colitis
Sepsis
Pharmaceutical Preparations

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

Asacol®-induced neutropenia resolution without the use of granulocyte colony-stimulating factor. / Fowler, Brian T.; Gupta, Tina; Bilal, Muhammad.

In: Southern Medical Journal, Vol. 103, No. 11, 01.11.2010, p. 1167-1169.

Research output: Contribution to journalArticle

@article{e738a6ad023e41dfa3ab3f6a8bce693f,
title = "Asacol{\circledR}-induced neutropenia resolution without the use of granulocyte colony-stimulating factor",
abstract = "We report a case of neutropenia and gram-negative septicemia in a 73-year-old male with ulcerative colitis. During the hospital course, medications were adjusted according to rare accounts of drug-induced neutropenia. While the substitution of propafenone for another antiarrhythmic brought about no change in the patient's absolute neutrophil count, the cessation of Asacol{\circledR} (Warner Chilcott, Rockaway, NJ) was followed by a significant improvement in the neutropenic state. In fact, this neutrophil count continued to trend upward for months following. We thereby conclude that Asacol{\circledR} carries the potential to induce neutropenia and that this reaction may be reversed in some patients solely by discontinuing the medication and without the aid of stimulating factors such as filgrastim.",
author = "Fowler, {Brian T.} and Tina Gupta and Muhammad Bilal",
year = "2010",
month = "11",
day = "1",
doi = "10.1097/SMJ.0b013e3181f46647",
language = "English (US)",
volume = "103",
pages = "1167--1169",
journal = "Southern Medical Journal",
issn = "0038-4348",
publisher = "Lippincott Williams and Wilkins",
number = "11",

}

TY - JOUR

T1 - Asacol®-induced neutropenia resolution without the use of granulocyte colony-stimulating factor

AU - Fowler, Brian T.

AU - Gupta, Tina

AU - Bilal, Muhammad

PY - 2010/11/1

Y1 - 2010/11/1

N2 - We report a case of neutropenia and gram-negative septicemia in a 73-year-old male with ulcerative colitis. During the hospital course, medications were adjusted according to rare accounts of drug-induced neutropenia. While the substitution of propafenone for another antiarrhythmic brought about no change in the patient's absolute neutrophil count, the cessation of Asacol® (Warner Chilcott, Rockaway, NJ) was followed by a significant improvement in the neutropenic state. In fact, this neutrophil count continued to trend upward for months following. We thereby conclude that Asacol® carries the potential to induce neutropenia and that this reaction may be reversed in some patients solely by discontinuing the medication and without the aid of stimulating factors such as filgrastim.

AB - We report a case of neutropenia and gram-negative septicemia in a 73-year-old male with ulcerative colitis. During the hospital course, medications were adjusted according to rare accounts of drug-induced neutropenia. While the substitution of propafenone for another antiarrhythmic brought about no change in the patient's absolute neutrophil count, the cessation of Asacol® (Warner Chilcott, Rockaway, NJ) was followed by a significant improvement in the neutropenic state. In fact, this neutrophil count continued to trend upward for months following. We thereby conclude that Asacol® carries the potential to induce neutropenia and that this reaction may be reversed in some patients solely by discontinuing the medication and without the aid of stimulating factors such as filgrastim.

UR - http://www.scopus.com/inward/record.url?scp=78549281710&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=78549281710&partnerID=8YFLogxK

U2 - 10.1097/SMJ.0b013e3181f46647

DO - 10.1097/SMJ.0b013e3181f46647

M3 - Article

VL - 103

SP - 1167

EP - 1169

JO - Southern Medical Journal

JF - Southern Medical Journal

SN - 0038-4348

IS - 11

ER -