Assessing the relationship between neurocognitive performance and brain volume in chronic moderate-severe traumatic brain injury

Nikos Konstantinou, Eva Pettemeridou, Ioannis Seimenis, Eleni Eracleous, Savvas S. Papacostas, Andrew Papanicolaou, Fofi Constantinidou

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Objectives: Characterize the scale and pattern of long-term atrophy in gray matter (GM), white matter (WM), and cerebrospinal fluid (CSF) in chronic moderate-severe traumatic brain injury (TBI) and its relationship to neurocognitive outcomes. Participants: The TBI group consisted of 17 males with primary diagnosis of moderate-severe closed head injury. Participants had not received any systematic, post-acute rehabilitation and were recruited on average 8.36 years post-injury. The control group consisted of 15 males matched on age and education. Main measures: Neurocognitive battery included widely used tests of verbal memory, visual memory, executive functioning, and attention/organization. GM, WM, and CSF volumes were calculated from segmented T1-weighted anatomical MR images. Voxel-based morphometry was employed to identify brain regions with differences in GM and WM between TBI and control groups. Results: Chronic TBI results in significant neurocognitive impairments, and significant loss of GM and WM volume, and significant increase in CSF volume. Brain atrophy is not widespread, but it is rather distributed in a fronto-thalamic network. The extent of volume loss is predictive of performance on the neurocognitive tests. Conclusion: Significant brain atrophy and associated neurocognitive impairments during the chronic stages of TBI support the notion that TBI results in a chronic condition with lifelong implications.

Original languageEnglish (US)
Article number29
JournalFrontiers in Neurology
Volume7
Issue numberMAR
DOIs
StatePublished - Mar 10 2016

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Brain
Atrophy
Cerebrospinal Fluid
Chronic Brain Injury
Closed Head Injuries
Control Groups
Traumatic Brain Injury
Rehabilitation
Education
White Matter
Gray Matter
Wounds and Injuries

All Science Journal Classification (ASJC) codes

  • Neurology
  • Clinical Neurology

Cite this

Konstantinou, N., Pettemeridou, E., Seimenis, I., Eracleous, E., Papacostas, S. S., Papanicolaou, A., & Constantinidou, F. (2016). Assessing the relationship between neurocognitive performance and brain volume in chronic moderate-severe traumatic brain injury. Frontiers in Neurology, 7(MAR), [29]. https://doi.org/10.3389/fneur.2016.00029

Assessing the relationship between neurocognitive performance and brain volume in chronic moderate-severe traumatic brain injury. / Konstantinou, Nikos; Pettemeridou, Eva; Seimenis, Ioannis; Eracleous, Eleni; Papacostas, Savvas S.; Papanicolaou, Andrew; Constantinidou, Fofi.

In: Frontiers in Neurology, Vol. 7, No. MAR, 29, 10.03.2016.

Research output: Contribution to journalArticle

Konstantinou, N, Pettemeridou, E, Seimenis, I, Eracleous, E, Papacostas, SS, Papanicolaou, A & Constantinidou, F 2016, 'Assessing the relationship between neurocognitive performance and brain volume in chronic moderate-severe traumatic brain injury', Frontiers in Neurology, vol. 7, no. MAR, 29. https://doi.org/10.3389/fneur.2016.00029
Konstantinou, Nikos ; Pettemeridou, Eva ; Seimenis, Ioannis ; Eracleous, Eleni ; Papacostas, Savvas S. ; Papanicolaou, Andrew ; Constantinidou, Fofi. / Assessing the relationship between neurocognitive performance and brain volume in chronic moderate-severe traumatic brain injury. In: Frontiers in Neurology. 2016 ; Vol. 7, No. MAR.
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