Assessment of cerebrovascular resistance with a model of cerebrovascular pressure transmission

Nithya Narayanan, Charles Leffler, Michael L. Daley

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

A method to assess continuous changes of cerebrovascular resistance based on a biomechanical model of cerebrovascular pressure transmission is developed. Such a method provides an end-point measure to assess new and/or existing management strategies during intensive-care management of patients with brain injury. Changes of both pial arteriolar resistance and cerebrovascular resistance derived by a physiologically based biomechanical model of cerebrovascular pressure transmission, the dynamic relationship between arterial blood pressure (ABP) and intracranial pressure (ICP), were compared to test the validity of the modeling procedure. Pressor challenge was administered to normoxic (N = 5) and hypoxic (N = 5) piglets equipped with closed cranial windows. Pial arteriolar diameters were used to compute arteriolar resistance. Percent change of pial arteriolar resistance (%ΔPAR) and percent change of model-derived cerebrovascular resistance (%ΔsCVR) in response to pressor challenge were computed. During intact cerebrovascular regulation and during hypoxia-induced impairment of cerebrovascular regulation, changes in pial arteriolar resistance were accurately predicted by the proposed modeling method designed to assess changes of cerebrovascular resistance.

Original languageEnglish (US)
Pages (from-to)254-260
Number of pages7
JournalMedical Engineering and Physics
Volume31
Issue number2
DOIs
StatePublished - Mar 1 2009

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Pressure
Blood pressure
Brain
Intracranial Pressure
Critical Care
Brain Injuries
Arterial Pressure
Hypoxia

All Science Journal Classification (ASJC) codes

  • Biophysics
  • Biomedical Engineering

Cite this

Assessment of cerebrovascular resistance with a model of cerebrovascular pressure transmission. / Narayanan, Nithya; Leffler, Charles; Daley, Michael L.

In: Medical Engineering and Physics, Vol. 31, No. 2, 01.03.2009, p. 254-260.

Research output: Contribution to journalArticle

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