Assessment of functional cerebral laterality for language using magnetoencephalography

Panagiotis G. Simos, Joshua I. Breier, George Zouridakis, Andrew Papanicolaou

Research output: Contribution to journalArticle

58 Citations (Scopus)

Abstract

The purpose of the study was to examine the feasibility of using magnetoencephalography (MEG), a noninvasive functional brain imaging technique, to assess cerebral laterality for language. The magnetic flux normal to the scalp surface was measured with a whole-head neuromagnetometer while subjects (n = 16) were engaged in a word-matching and a tone-matching task. The effect of hemisphere and task on the number of satisfactory equivalent current dipole (ECD) solutions obtained during the late portion of the responses to the word and tone stimuli was examined. An interhemispheric ECD laterality index was also computed. Satisfactory ECD solutions were localized in perisylvian cortices during both tasks. A greater number of ECDs was found in the left hemisphere in 14 (87%) of 16 of the subjects in the word-matching task, a proportion that approaches the reported incidence of left-hemisphere dominance among right-handers. A similar proportion of subjects also showed a clear asymmetry in the number of ECDs favoring the left hemisphere in the language task as compared to the nonlanguage task. These findings suggest that MEG is a promising tool for laterality assessment. Magnetoencephalography-based functional asymmetry data are currently being compared against invasive presurgical procedures (i.e., intracarotid amobarbital procedure).

Original languageEnglish (US)
Pages (from-to)364-372
Number of pages9
JournalJournal of Clinical Neurophysiology
Volume15
Issue number4
DOIs
StatePublished - Jan 1 1998

Fingerprint

Magnetoencephalography
Functional Laterality
Language
Amobarbital
Functional Neuroimaging
Scalp
Head
Incidence

All Science Journal Classification (ASJC) codes

  • Physiology
  • Neurology
  • Clinical Neurology
  • Physiology (medical)

Cite this

Assessment of functional cerebral laterality for language using magnetoencephalography. / Simos, Panagiotis G.; Breier, Joshua I.; Zouridakis, George; Papanicolaou, Andrew.

In: Journal of Clinical Neurophysiology, Vol. 15, No. 4, 01.01.1998, p. 364-372.

Research output: Contribution to journalArticle

Simos, Panagiotis G. ; Breier, Joshua I. ; Zouridakis, George ; Papanicolaou, Andrew. / Assessment of functional cerebral laterality for language using magnetoencephalography. In: Journal of Clinical Neurophysiology. 1998 ; Vol. 15, No. 4. pp. 364-372.
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