Assessment of hemispheric dominance for receptive language in pediatric patients under sedation using magnetoencephalography

Roozbeh Rezaie, Shalini Narayana, Katherine Schiller, Liliya Birg, James Wheless, Frederick Boop, Andrew C. Papanicolaou

Research output: Contribution to journalReview article

10 Citations (Scopus)

Abstract

Non-invasive assessment of hemispheric dominance for receptive language using magnetoencephalography (MEG) is now a well-established procedure used across several epilepsy centers in the context of pre-surgical evaluation of children and adults while awake, alert and attentive. However, the utility of MEG for the same purpose, in cases of sedated patients, is contested. Establishment of the efficiency of MEG is especially important in the case of children who, for a number of reasons, must be assessed under sedation. Here we explored the efficacy of MEG language mapping under sedation through retrospective review of 95 consecutive pediatric patients, who underwent our receptive language test as part of routine clinical evaluation. Localization of receptive language cortex and subsequent determination of laterality was successfully completed in 78% (n=36) and 55% (n=27) of non-sedated and sedated patients, respectively. Moreover, the proportion of patients deemed left hemisphere dominant for receptive language did not differ between nonsedated and sedated patients, exceeding 90% in both groups. Considering the challenges associated with assessing brain function in pediatric patients, the success of passive MEG in the context of the cases reviewed in this study support the utility of this method in pre-surgical receptive language mapping.

Original languageEnglish (US)
Article number657
JournalFrontiers in Human Neuroscience
Volume8
Issue numberAUG
DOIs
StatePublished - Aug 21 2014

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Magnetoencephalography
Language
Pediatrics
Language Tests
Epilepsy
Brain

All Science Journal Classification (ASJC) codes

  • Neuropsychology and Physiological Psychology
  • Neurology
  • Psychiatry and Mental health
  • Biological Psychiatry
  • Behavioral Neuroscience

Cite this

Assessment of hemispheric dominance for receptive language in pediatric patients under sedation using magnetoencephalography. / Rezaie, Roozbeh; Narayana, Shalini; Schiller, Katherine; Birg, Liliya; Wheless, James; Boop, Frederick; Papanicolaou, Andrew C.

In: Frontiers in Human Neuroscience, Vol. 8, No. AUG, 657, 21.08.2014.

Research output: Contribution to journalReview article

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