Assessment of the biocompatibility of two novel, bionanocomposite scaffolds in a rodent model

C. R. Deeken, M. Esebua, S. L. Bachman, B. J. Ramshaw, S. A. Grant

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

Two novel, bionanocomposite scaffolds were evaluated in a rodent model over the course of three months to determine whether these scaffolds possessed adequate biocompatibility characteristics to warrant further evaluation as possible tissue reconstruction scaffolds. These bionanocomposite scaffolds were comprised of amine-functionalized gold nanoparticles (AuNP) or silicon carbide nanowires (SiCNW) crosslinked to an acellular porcine diaphragm tendon. It was hypothesized that the addition of nanomaterials to the porcine tendon would also improve its biocompatibility by imparting a nanostructured surface. As early as seven days after implantation, both types of bionanocomposite scaffolds displayed evidence of granulation tissue and the beginning of scaffold remodeling with new collagen deposited by the host, and by ninety-seven days the bionanocomposite scaffolds were completely remodeled with no evidence of any adverse host tissue reaction or scar tissue formation. The AuNP bionanocomposite scaffolds exhibited accelerated scaffold remodeling compared to the SiCNW scaffolds.

Original languageEnglish (US)
Pages (from-to)351-359
Number of pages9
JournalJournal of Biomedical Materials Research - Part B Applied Biomaterials
Volume96 B
Issue number2
DOIs
StatePublished - Feb 1 2011

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Scaffolds (biology)
Biocompatibility
Scaffolds
Tissue Scaffolds
Tissue
Tendons
Nanowires
Silicon carbide
Granulation
Diaphragms
Rodentia
Nanostructured materials
Gold
Amines
Collagen
Nanoparticles

All Science Journal Classification (ASJC) codes

  • Biomaterials
  • Biomedical Engineering

Cite this

Assessment of the biocompatibility of two novel, bionanocomposite scaffolds in a rodent model. / Deeken, C. R.; Esebua, M.; Bachman, S. L.; Ramshaw, B. J.; Grant, S. A.

In: Journal of Biomedical Materials Research - Part B Applied Biomaterials, Vol. 96 B, No. 2, 01.02.2011, p. 351-359.

Research output: Contribution to journalArticle

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